Olmesartan

Modify Date: 2024-01-02 18:00:19

Olmesartan Structure
Olmesartan structure
 Common Name Olmesartan
CAS Number 144689-24-7 Molecular Weight 446.502
Density 1.3±0.1 g/cm3 Boiling Point 738.3±70.0 °C at 760 mmHg
Molecular Formula C24H26N6O3 Melting Point 186-188ºC
MSDS Chinese USA Flash Point 400.3±35.7 °C

 Use of Olmesartan


Olmesartan is an angiotensin II receptor (AT1R) antagonist used to treat high blood pressure.

 Names

Name olmesartan
Synonym More Synonyms

 Olmesartan Biological Activity

Description Olmesartan is an angiotensin II receptor (AT1R) antagonist used to treat high blood pressure.
Related Catalog
In Vivo Repeated dosing of olmesartan (1 mg/kg, 2 mg/kg, p.o.) dose-dependently decreases mean arterial blood pressure (MAP) in SHR without significant influence on body weight and food intake during 10 weeks[1]. Olmesartan (5 mg/kg/d, p.o.) and Hyd treatments lower systolic blood pressure to the same degree in mice. Olmesartan treatment inhibits cardiac hypertrophy, evaluated by echocardiography, heart weight, cross-sectional area of cardiomyocytes, and gene expression. Olmesartan treatment reverses decreased gene expressions of ACE2 and Mas receptor of Ren-Tg mice and inhibits enhanced NADPH oxidase (Nox)4 expression and reactive oxygen species[2].
Animal Admin Seven week-old male spontaneously hypertensive rats (SHR) are divided into five groups and fed a high fat diet (HFD) (60% kcal as fat) ad libitum. SHR are treated with vehicle (1% tragacanth gum solution), telmisartan (1 mg/kg), telmisartan (2 mg/kg), olmesartan (1 mg/kg) or olmesartan (2 mg/kg) once daily by gastric gavage. After more than 4 weeks-treatment, mean arterial blood pressure is measured for 24 h under a conscious state.
References

[1]. Yanagihara H, et al. Effects of telmisartan and olmesartan on insulin sensitivity and renal function in spontaneously hypertensive rats fed a high fat diet. J Pharmacol Sci. 2016 Jul;131(3):190-7.

[2]. Tanno T, et al. Olmesartan Inhibits Cardiac Hypertrophy in Mice Overexpressing Renin Independently of Blood Pressure: Its Beneficial Effects on ACE2/Ang(1-7)/Mas Axis and NADPH Oxidase Expression. J Cardiovasc Pharmacol. 2016 Jun;67(6):503-9.

[3]. Komiya H, et al. Sleep/wakefulness behaviors in mice during pregnancy and pregnancy-associated hypertensive mice. Sleep. 2018 Mar 1;41(3).

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 738.3±70.0 °C at 760 mmHg
Melting Point 186-188ºC
Molecular Formula C24H26N6O3
Molecular Weight 446.502
Flash Point 400.3±35.7 °C
Exact Mass 446.206635
PSA 129.81000
LogP 3.72
Vapour Pressure 0.0±2.6 mmHg at 25°C
Index of Refraction 1.671
Storage condition -20°C Freezer

 Safety Information

Hazard Codes Xi
RIDADR NONH for all modes of transport
RTECS NI4014100
HS Code 2921590090

 Customs

HS Code 2921590090
Summary 2921590090. other aromatic polyamines and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles4

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 Synonyms

4-(2-Hydroxy-2-propanyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-imidazole-5-carboxylic acid
Olmesartan Acid
MFCD00914967
Olmesartan
5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid
1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
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Related Compounds: More...
Olmesartan
144689-78-1
Olmesartan
1185144-74-4
Olmesartan D4
1420880-41-6
trityl olmesartan
761404-85-7
Dehydro Olmesartan
172875-98-8
Olmesartan impurity
154709-18-9
Olmesartan medoxomil
144689-63-4
Olmesartan monohydrate
913529-31-4
Olmesartan ethyl ester
144689-23-6
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1158522-08-7
4-({1-[(3-Methylphenyl)methanesulfonyl]piperidin-3-yl}methoxy)pyridine
2379997-54-1
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
940364-43-2
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
134104-43-1
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
131615-57-1
(4-Methyl-tetrahydro-furan-2-yl)-methanol
6906-52-1
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
930439-75-1
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
1018584-77-4
tert-Butyl-DL-alanine
1375289-11-4
4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide
849349-65-1
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