106730-54-5

106730-54-5 structure

Name: Olprinone
Chemical Name: 5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-1H-pyridine-3-carbonitrile
CAS Number: 106730-54-5
Molecular Formula: C₁₄H₁₀N₄O
Molecular Weight: 250.255
Catalog: API Circulatory system medication Anti-congestive heart failure medicine
Create Date: 2018-09-05 09:46:03
Modify Date: 2025-08-21 14:35:12
Olprinone(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor. IC50 value:Target: PDE3Olprinone is used as cardiotonic agent with positive inotropic and vasodilating effects. Olprinone has been reported to improve microcirculation and attenuate inflammation. Olprinone is often used to increase cardiac output after cardiopulmonary bypass (CPB). Olprinone was infused at a rate of 0.2 μg/kg/min when weaning from CPB was started. Olprinone has also shown potent antioxidative and anti-inflammatory effects in the meconium-induced oxidative lung injury.

Name	5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-1H-pyridine-3-carbonitrile
Synonyms	1,2-Dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxonicotinonitrile Olprinone [INN] 1,2-Dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile 5-(Imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile UNII-4Y8BMI9YGC Loprinone Coretec 3-Pyridinecarbonitrile, 1,2-dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo- MFCD00868774 Olprinone 1,2-dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile 5-(Imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile Olprinone\|

Description	Olprinone(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor. IC50 value:Target: PDE3Olprinone is used as cardiotonic agent with positive inotropic and vasodilating effects. Olprinone has been reported to improve microcirculation and attenuate inflammation. Olprinone is often used to increase cardiac output after cardiopulmonary bypass (CPB). Olprinone was infused at a rate of 0.2 μg/kg/min when weaning from CPB was started. Olprinone has also shown potent antioxidative and anti-inflammatory effects in the meconium-induced oxidative lung injury.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Cardiovascular Disease
References	[1]. Tsubokawa T, Ishizuka S, Fukumoto K, et al. The effect of hemodilution by cardiopulmonary bypass on protein binding of olprinone. J Anesth. 2012 . [2]. Mokra D, Drgova A, Pullmann R Sr, et al. Selective phosphodiesterase 3 inhibitor olprinone attenuates meconium-induced oxidative lung injury. Pulm Pharmacol Ther. 2012 Jun;25(3):216-22. [3]. Yamanaka H, Hayashi Y, Kamibayashi T, Mashimo T. Effect of olprinone, a phosphodiesterase III inhibitor, on balance of cerebral oxygen supply and demand during cardiopulmonary bypass. J Cardiovasc Pharmacol. 2011 May;57(5):579-83. [4]. Mazzon E, Esposito E, Di Paola R, et al. Olprinone, a specific phosphodiesterase (PDE)-III inhibitor, reduces the development of multiple organ dysfunction syndrome in mice. Pharmacol Res. 2011 Jul;64(1):68-79.

Density	1.3±0.1 g/cm3
Melting Point	>300ºC
Molecular Formula	C₁₄H₁₀N₄O
Molecular Weight	250.255
Exact Mass	250.085464
PSA	73.95000
LogP	1.03
Index of Refraction	1.703

Hazard Codes	T,N,C
Risk Phrases	R25:Toxic if swallowed. R34:Causes burns. R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment . R24/25:Toxic in contact with skin and if swallowed . R36:Irritating to the eyes.
Safety Phrases	S26-S36-S45-S61-S36/37/39
RIDADR	UN 2922 8/PG 2
WGK Germany	3
RTECS	AK5110000
Packaging Group	II
Hazard Class	8
HS Code	29183000

106730-70-5

107-91-5

~51%

106730-54-5

Literature: Yamanaka; Miyake; Suda; Ohhara; Ogawa Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 6 p. 1556 - 1567

1072-97-5

106730-54-5

Literature: Chemical and Pharmaceutical Bulletin, , vol. 39, # 6 p. 1556 - 1567

36052-24-1

106730-54-5

Literature: Chemical and Pharmaceutical Bulletin, , vol. 39, # 6 p. 1556 - 1567

116355-16-9

106730-54-5

Literature: Chemical and Pharmaceutical Bulletin, , vol. 39, # 6 p. 1556 - 1567

116355-20-5

106730-54-5

Literature: Chemical and Pharmaceutical Bulletin, , vol. 39, # 6 p. 1556 - 1567

116355-08-9

106730-54-5

Literature: Chemical and Pharmaceutical Bulletin, , vol. 39, # 6 p. 1556 - 1567

136117-69-6

106730-54-5

Literature: Chemical and Pharmaceutical Bulletin, , vol. 39, # 6 p. 1556 - 1567

6188-23-4

106730-54-5

Literature: Chemical and Pharmaceutical Bulletin, , vol. 39, # 6 p. 1556 - 1567

Precursor 9
106730-70-5 107-91-5 1072-97-5 36052-24-1
116355-16-9 116355-20-5 116355-08-9 136117-69-6
6188-23-4
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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