146665-77-2

146665-77-2 structure

Name: sunpla
Chemical Name: Eptaplatin
CAS Number: 146665-77-2
Molecular Formula: C₁₁H₂₀N₂O₆Pt
Molecular Weight: 471.36
Catalog: Research Areas Cancer
Create Date: 2018-04-21 08:00:00
Modify Date: 2025-08-22 15:57:09
Heptaplatin (SKI 2053R) is a platinum derivative with anticancer activity against various cancer cell lines, including cisplatin-resistant tumor cell lines. SKI-2053R is active in the research of gastric adenocarcinoma and has favorable toxicity profiles[1].

Name	Eptaplatin
Synonyms	[propanedioato(2-)-κO,O]platinum - [(4R,5R)-2-(propan-2-yl)-1,3-dioxolane-4,5-diyl]dimethanamine (1:1) (SP-4-2)-[(4R,5R)-2-Isopropyl-1,3-dioxolane-4,5 Platinum(2+) malonate [(4R,5R)-2-isopropyl-1,3-dioxolane-4,5-diyl]dimethanamine (1:1:1) platinum, [propanedioato(2-)-κO,κO]-, compd. with (4R,5R)-2-(1-methylethyl)-1,3-dioxolane-4,5-dimethanamine (1:1) EPTAPLATIN,SUNPLA SKI 2053R [Malonato(2-)-κO,O]platinum - [(4R,5R)-2-isopropyl-1,3-dioxolane-4,5-diyl]dimethanamine (1:1) sunpla EPOXYPROGESTERONE Heptaplatin cis-[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane](malonate)platinum(II) (SP-4-2)-[(4R,5R)-2-ISOPROPYL-1,3-DIOXOLANE-4,5-BIS(METHANAMINE)-N,N'][PROPANEDIOATO(2-)-O,O']PLATINUM

Description	Heptaplatin (SKI 2053R) is a platinum derivative with anticancer activity against various cancer cell lines, including cisplatin-resistant tumor cell lines. SKI-2053R is active in the research of gastric adenocarcinoma and has favorable toxicity profiles[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Kim NK, et al. Phase II clinical trial of SKI-2053R, a new platinum analog, in the treatment of patients with advanced gastric adenocarcinoma. Cancer. 1999;86(7):1109-1115.

Boiling Point	261.5ºC at 760 mmHg
Melting Point	43-49ºC
Molecular Formula	C₁₁H₂₀N₂O₆Pt
Molecular Weight	471.36
Flash Point	114ºC
Exact Mass	471.096924
PSA	123.10000
LogP	0.45950
Vapour Pressure	0.0115mmHg at 25°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TP2505900

CHEMICAL NAME :: Platinum, (2-(1-methylethyl)-1,3-dioxolane-4,5-dimethanamine-N, N')(propanedioato(2-) -O,O')-, (SP-4-2-(4R-(2-alpha,4-alpha,5-beta)))-

CAS REGISTRY NUMBER :: 146665-77-2

LAST UPDATED :: 199509

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C11-H20-N2-O6-Pt

MOLECULAR WEIGHT :: 471.42

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KJTOEA Korean Journal of Toxicology. (Korean Society of Toxicology, c/o College of Medicine, Seoul National University, Seoul, 110, S. Korea) V.1- 1985- Volume(issue)/page/year: 8,205,1993

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 182 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KJTOEA Korean Journal of Toxicology. (Korean Society of Toxicology, c/o College of Medicine, Seoul National University, Seoul, 110, S. Korea) V.1- 1985- Volume(issue)/page/year: 8,205,1993

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1590 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KJTOEA Korean Journal of Toxicology. (Korean Society of Toxicology, c/o College of Medicine, Seoul National University, Seoul, 110, S. Korea) V.1- 1985- Volume(issue)/page/year: 8,205,1993

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 198 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KJTOEA Korean Journal of Toxicology. (Korean Society of Toxicology, c/o College of Medicine, Seoul National University, Seoul, 110, S. Korea) V.1- 1985- Volume(issue)/page/year: 8,205,1993 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 235 mg/kg/13W-I

TOXIC EFFECTS :: Blood - normocytic anemia Blood - changes in leukocyte (WBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: KJTOEA Korean Journal of Toxicology. (Korean Society of Toxicology, c/o College of Medicine, Seoul National University, Seoul, 110, S. Korea) V.1- 1985- Volume(issue)/page/year: 8,217,1992

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 15 mg/kg/90D-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Related to Chronic Data - death

REFERENCE :: KJTOEA Korean Journal of Toxicology. (Korean Society of Toxicology, c/o College of Medicine, Seoul National University, Seoul, 110, S. Korea) V.1- 1985- Volume(issue)/page/year: 8,235,1992

Hazard Codes	Xn

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

565173-01-5	356086-27-6
782455-03-2	332382-56-6
312622-07-4	6051-02-1
389066-42-6	1289027-86-6
2138410-16-7	1854370-50-5