843666-40-0

843666-40-0 structure

Name: Boc-C16-COOH
Chemical Name: 18-[(2-methylpropan-2-yl)oxy]-18-oxooctadecanoic acid
CAS Number: 843666-40-0
Molecular Formula: C₂₂H₄₂O₄
Molecular Weight: 370.56600
Catalog: Organic raw materials Carboxylic compounds and derivatives Acyclic carboxylic acid
Create Date: 2018-06-24 21:28:07
Modify Date: 2024-01-04 10:25:58
Boc-C16-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-C16-COOH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]

Name	18-[(2-methylpropan-2-yl)oxy]-18-oxooctadecanoic acid
Synonyms	Octadecanedioicacid,mono(1,1-dimethylethyl) ester (9CI) Octadecanedioic acid,1-(1,1-dimethylethyl) ester Octadecanedioic acid mono-tert-butyl ester 18-tert-butoxy-18-oxooctadecanoic acid

Description	Boc-C16-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-C16-COOH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Hazard Codes	Xn
HS Code	2918990090

871-70-5

36805-97-7

843666-40-0

Literature: Novo Nordisk A/S Patent: US2011/306551 A1, 2011 ;

Precursor 2
871-70-5 36805-97-7
DownStream 0

HS Code	2918990090
Summary	2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%