40580-59-4
40580-59-4 structure
- Name: guanadrel
- Chemical Name: guanadrel
- CAS Number: 40580-59-4
- Molecular Formula: C10H19N3O2
- Molecular Weight: 213.27700
- Catalog: API Circulatory system medication Antihypertensive drug
- Create Date: 2018-03-09 08:00:00
- Modify Date: 2024-01-04 17:16:29
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Guanadrel is an orally active postganglionic adrenergic inhibitor of spiroketal. Guanadre can be used in anti-hypertensive studies[1].
| Name | guanadrel |
|---|---|
| Synonyms |
1-(1,4-Dioxaspiro[4.5]decan-2-ylmethyl)guanidine
Guanadrel |
| Description | Guanadrel is an orally active postganglionic adrenergic inhibitor of spiroketal. Guanadre can be used in anti-hypertensive studies[1]. |
|---|---|
| Related Catalog | |
| In Vivo | Guanadrel (oral gavage, 15-400 mg/kg, every day, 6-52 weeks) has little toxicity to the nervous system in rats and dogs[1]. Animal Model: Rats, dogs[1] Dosage: 15-400 mg/kg Administration: Oral gavage; every day; 6-52 weeks Result: Showed a slight increase in the weight of the prostate and adrenal glands while loss in the kidney in rats. Decreased weight gain values in a dose-dependent manner but liver function is normal in dogs. |
| References |
| Density | 1.39g/cm3 |
|---|---|
| Boiling Point | 387.9ºC at 760 mmHg |
| Melting Point | 213.5-215ºC |
| Molecular Formula | C10H19N3O2 |
| Molecular Weight | 213.27700 |
| Flash Point | 188.4ºC |
| Exact Mass | 213.14800 |
| PSA | 80.36000 |
| LogP | 1.73620 |
| Index of Refraction | 1.618 |