guanadrel

Modify Date: 2024-01-04 17:16:29

guanadrel structure	Common Name	guanadrel
	CAS Number	40580-59-4	Molecular Weight	213.27700
	Density	1.39g/cm3	Boiling Point	387.9ºC at 760 mmHg
	Molecular Formula	C₁₀H₁₉N₃O₂	Melting Point	213.5-215ºC
	MSDS	N/A	Flash Point	188.4ºC

Use of guanadrel

Guanadrel is an orally active postganglionic adrenergic inhibitor of spiroketal. Guanadre can be used in anti-hypertensive studies[1].

Name	guanadrel
Synonym	More Synonyms

Description	Guanadrel is an orally active postganglionic adrenergic inhibitor of spiroketal. Guanadre can be used in anti-hypertensive studies[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
In Vivo	Guanadrel (oral gavage, 15-400 mg/kg, every day, 6-52 weeks) has little toxicity to the nervous system in rats and dogs[1]. Animal Model: Rats, dogs[1] Dosage: 15-400 mg/kg Administration: Oral gavage; every day; 6-52 weeks Result: Showed a slight increase in the weight of the prostate and adrenal glands while loss in the kidney in rats. Decreased weight gain values in a dose-dependent manner but liver function is normal in dogs.
References	[1]. J D Palmer, et al. Guanadrel sulfate: a postganglionic sympathetic inhibitor for the treatment of mild to moderate hypertension. Pharmacotherapy. 1983 Jul-Aug;3(4):220-9. doi: 10.1002/j.1875-9114.1983.tb03257.x.

Density	1.39g/cm3
Boiling Point	387.9ºC at 760 mmHg
Melting Point	213.5-215ºC
Molecular Formula	C₁₀H₁₉N₃O₂
Molecular Weight	213.27700
Flash Point	188.4ºC
Exact Mass	213.14800
PSA	80.36000
LogP	1.73620
Index of Refraction	1.618

1-(1,4-Dioxaspiro[4.5]decan-2-ylmethyl)guanidine

Guanadrel