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Product Name: Ethanamine,2-[(4-bromophenyl)phenylmethoxy]-N,N-dimethyl-, hydrochloride (1:1)
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1808-12-4

1808-12-4 structure

Name: Bromodiphenhydramine hydrochloride
Chemical Name: bromazine hydrochloride
CAS Number: 1808-12-4
Molecular Formula: C₁₇H₂₁BrClNO
Molecular Weight: 370.71200
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-06-18 20:39:25
Modify Date: 2026-07-02 19:59:10
Bromodiphenhydramine hydrochloride is a potent antihistamine with antimicrobial property. Bromodiphenhydramine hydrochloride inhibits a large number of Gram negative and Gram positive bacteria. Bromodiphenhydramine hydrochloride can be used for cutaneous allergies research[1][2][3].

Name	bromazine hydrochloride
Synonyms	Diphenhydramine Impurity 3（Diphenhydramine Impurity C） EINECS -8 Bromazine hydrochloride EINECS 217-310-9 2-((p-bromo-alpha-phenylbenzyl)oxy)-n,n-dimethylethylaminehydrochloride Bromodiphenhydramine hydrochloride, 10 mM in DMSO Bromdiphenylhydramine hydrochloride IMp. H as Hydrochloride: 2-[(RS)-(4- BroMophenyl)(phenyl)Methoxy]-N,N-diMethyl- ethanaMine Hydrochloride (4-BroModiphen- hydraMine Hydrochloride Diphenhydramine Impurity 3 (Diphenhydramine Impurity C HCl) Bromodiphenhydramine Hydrochloride deserol [2-(4-Brom-benzhydryloxy)-aethyl]-dimethyl-amin,Hydrochlorid 2-((4-bromophenyl)phenylmethoxy)-n,n-dimethyl-ethanaminhydrochloride bromo-benzdryl Bromazine Hydrochloride 1.0 mg/ml in Methanol (as free base) Bromodiphenhydramine HCl Cetirizine-d 2-[(4-bromophenyl)phenylmethoxy]-N,N-dimethyl-ethanamine,hydrochloride bromazin 2-[(RS)-(4-Bromophenyl)phenylmethoxy]-N,N-dimethylethanamine hydrochloride bromodiphenhydraminehydrochloride 2-[(4-bromophenyl)phenylmethoxy]ethyl(dimethyl)ammonium chloride Bromdiphenhydramine hydrochloride Diphenhydramine Impurity C hydrochloride phenyl(p-bromophenyl)(dimethylaminoethoxy)methane hydrochloride Dimenhydrinate Impurity H as Hydrochloride 2-(4-BroModiphenylMethoxy)ethyldiMethylaMine Hydrochloride beta-(p-bromobenzhydryloxy)ethyldimethylaminehydrochloride 2-[(p-BroMo-α-phenylbenzyl)oxy]-N,N-diMethylethylaMine Hydrochloride 4-bromo-alpha-phenylbenzyl2-dimethylaminoethylether Diphenhydramine Impurity C HCl (Bromazine Hydrochloride) bacteria,inhibit,Inhibitor,antihistamine,Salmonella typhimurium,Histamine Rector,Bromodiphenhydramine,Bromodiphenhydramine hydrochloride,cutaneous allergies,Bacterial,Ambodryl bromdiphenylhydraminehydrochloride Diphenhydramine Impurity C HCl 2-(4-bromobenzohydryloxy)-ethyl-dimethylaminehydrochloride ambodrylhydrochloride DIPHENHYDRAMINE IMP C Bromazine HCl Diphenhydramine hydrochloride Impurity C 2-((p-bromo-alpha-phenylbenzyl)oxy)-n,n-dimethyl-ethylaminhydrochloride 2-[(4-bromophenyl)-phenylmethoxy]ethyl-dimethylazanium,chloride 2-(4-bromodiphenylmethoxy)ethyldimethylamine Diphenhydramine Hydrochloride Impurity C as Hydrochloride Dimenhydrinate Impurity H HCl (Diphenhydramine Impurity C HCl) 2-[(4-BroMophenyl)phenylMethoxy]-N,N-diMethylethanaMine Hydrochloride [2-(4-bromo-benzhydryloxy)-ethyl]-dimethyl-amine,hydrochloride

Description	Bromodiphenhydramine hydrochloride is a potent antihistamine with antimicrobial property. Bromodiphenhydramine hydrochloride inhibits a large number of Gram negative and Gram positive bacteria. Bromodiphenhydramine hydrochloride can be used for cutaneous allergies research[1][2][3].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Infection Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Anti-infection >> Bacterial
In Vivo	Bromodiphenhydramine hydrochloride (1.5 and 3 μg/g, single) protects mice against a challenge with a virulent strain of Salmonella typhimurium, and also significantly reduces the multiplication of this organism in the liver, spleen and blood of the protected animals in comparison with the unprotected controls[2].
References	[1]. MOLINA EB. [A new antihistaminic, bromodiphenhydramine hydrochloride, in the control of cutaneous allergies]. Sem Med. 1960 Jul 11;117:151-2. Spanish. [2]. Dastidar SG, et al. Antibacterial activity of ambodryl and benadryl. J Appl Bacteriol. 1976 Oct;41(2):209-14. [3]. Ray S, et al. Studies on synergism between penicillins and ambodryl (bromodiphenhydramine HCl), an antihistamine with antimicrobial property. Indian J Exp Biol. 1990 Mar;28(3):253-8.

Boiling Point	397.3ºC at 760 mmHg
Molecular Formula	C₁₇H₂₁BrClNO
Molecular Weight	370.71200
Flash Point	194.1ºC
Exact Mass	369.05000
PSA	12.47000
LogP	4.91870
Vapour Pressure	1.61E-06mmHg at 25°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KQ8420000

CHEMICAL NAME :: Ethylamine, 2-((p-bromo-alpha-phenylbenzyl)oxy)-N,N-dimethyl-, hydrochloride

CAS REGISTRY NUMBER :: 1808-12-4

LAST UPDATED :: 199504

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C17-H20-Br-N-O.Cl-H

MOLECULAR WEIGHT :: 370.75

WISWESSER LINE NOTATION :: ER DYR&O2N1&1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 602 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 55 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 366 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 105 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 112,318,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 63 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 21 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada) *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81737 No. of Facilities: 805 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 805 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81737 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 82 (estimated) No. of Female Employees: 14 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
RIDADR	NONH for all modes of transport
HS Code	2922199090

118-23-0

1808-12-4

Literature: Medicinal Chemistry Research, , vol. 21, # 11 p. 3532 - 3540

29334-16-5

1808-12-4

Literature: Medicinal Chemistry Research, , vol. 21, # 11 p. 3532 - 3540

18066-89-2

1808-12-4

Literature: Medicinal Chemistry Research, , vol. 21, # 11 p. 3532 - 3540

Precursor 3
118-23-0 29334-16-5 18066-89-2
DownStream 0

HS Code	2922199090
Summary	2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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