Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: phenyltoloxamine
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Purity: 98.0%
Stocking Period: Inquiry
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Email: enquiry@dycnchem.com

92-12-6

92-12-6 structure

Name: phenyltoloxamine
Chemical Name: 2-(2-benzylphenoxy)-N,N-dimethylethanamine
CAS Number: 92-12-6
Molecular Formula: C₁₇H₂₁NO
Molecular Weight: 255.35500
Catalog: API Antiallergic Antihistamine
Create Date: 2018-08-08 12:14:58
Modify Date: 2025-08-27 22:12:14
Phenyltoloxamine (Bistrimin) is an antihistamine agent with sedative and analgesic effects. Phenyltoloxamine also has potent Sigma-1 receptor binding affinity (Ki: 160 nM)[1][2][3].

Name	2-(2-benzylphenoxy)-N,N-dimethylethanamine
Synonyms	Feniltolossamina [DCIT] Phenyltoloxamine Phenoxadrine Antin [2-(2-benzyl-phenoxy)-ethyl]-dimethyl-amine Histionex 2-Dimethylamino-1-(2-benzyl-phenoxy)-aethan Bistrimin Phenoxadrin UNII-K65LB6598J Phenyl-toloxamin Phentoloxamine Bristamin [2-(2-Benzyl-phenoxy)-aethyl]-dimethyl-amin

Description	Phenyltoloxamine (Bistrimin) is an antihistamine agent with sedative and analgesic effects. Phenyltoloxamine also has potent Sigma-1 receptor binding affinity (Ki: 160 nM)[1][2][3].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Sigma Receptor Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Target	Sigma 1 Receptor:160 nM (Ki)
In Vitro	Phenyltoloxamine (10-50 μM, 24 h) demonstrates cytotoxicity in EVSA-T cells[2]. Phenyltoloxamine exhibits potent Sigma 1 Receptor (S1R) binding affinity with a Ki value of 160 nM[3]. Phenyltoloxamine (100 μM) inhibits human liver macrosaml CYP2D6 enzyme by 99.0%[4].

Density	1.022g/cm3
Boiling Point	359.2ºC at 760 mmHg
Molecular Formula	C₁₇H₂₁NO
Molecular Weight	255.35500
Flash Point	106ºC
Exact Mass	255.16200
PSA	12.47000
LogP	3.21780
Index of Refraction	1.552

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KH2376000

CHEMICAL NAME :: Ethanamine, N,N-dimethyl-2-(2-(phenylmethyl)phenoxy)-

CAS REGISTRY NUMBER :: 92-12-6

BEILSTEIN REFERENCE NO. :: 1986598

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C17-H21-N-O

MOLECULAR WEIGHT :: 255.39

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year: 2,17,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1127 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year: 2,17,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 246 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year: 2,17,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 55 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year: 2,17,1963 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83250 No. of Facilities: 19 (estimated) No. of Industries: 1 No. of Occupations: 9 No. of Employees: 934 (estimated) No. of Female Employees: 506 (estimated)

28994-41-4

92-12-6

Literature: Journal of Medicinal Chemistry, , vol. 47, # 17 p. 4155 - 4158

165683-42-1

124-40-3

92-12-6

Literature: Journal of Medicinal Chemistry, , vol. 24, # 2 p. 145 - 148

7563-58-8

107-99-3

92-12-6

Literature: Journal of the American Chemical Society, , vol. 71, p. 60,62

Precursor 5
28994-41-4 165683-42-1 124-40-3 7563-58-8
107-99-3
DownStream 1
111500-79-9

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