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53917-42-3

53917-42-3 structure
53917-42-3 structure
  • Name: ACTH (18-39) (human)
  • Chemical Name: Adrenocorticotropic Hormone
  • CAS Number: 53917-42-3
  • Molecular Formula: C112H165N27O36
  • Molecular Weight: 2465.67000
  • Catalog: Peptides
  • Create Date: 2019-02-16 20:43:20
  • Modify Date: 2024-01-01 23:43:41
  • Adrenocorticotropic Hormone (ACTH) (18-39), human is a corticotropinlike intermediate lobe peptide, which is is produced in the melanotrophs of the intermediate lobe of the pituitary.

Name Adrenocorticotropic Hormone
Synonyms CLIP
ProteoMass™ ACTH Fragment 18-39 MALDI-MS
Adrenocorticotropic hormone fragment 18-39
ARG-PRO-VAL-LYS-VAL-TYR-PRO-ASN-GLY-ALA-GLU-ASP-GLU-SER-ALA-GLU-ALA-PHE-PRO-LEU-GLU-PHE: RPVKVYPNGAEDESAEAFPLEF
ACTH (18-39) (HUMAN)
Adrenocorticotropic Hormone (ACTH) (18-39), human
Description Adrenocorticotropic Hormone (ACTH) (18-39), human is a corticotropinlike intermediate lobe peptide, which is is produced in the melanotrophs of the intermediate lobe of the pituitary.
Related Catalog
In Vitro The ACTH family of polypeptides consists of ACTH(1-39) (adrenocorticotropin), ACTH (1-13)amide (α-melanotropin;α-MSH); and ACTH (18-39) (corticotropinlike intermediate lobe peptide, CLIP). These polypeptides are derived from a common precursor, proopiomelanocortin. In corticotropic cells of the pars distalis, proopiomelanocortin (POMC) undergoes a series of proteolytic cleavage reactions to yield ACTH (1-39) as a major end product. However, in the melanotropic cells of the pars intermedia, an additional set of proteolytic reactions results in the conversion of ACTH (1-39) to ACTH (1-13) amide and ACTH (18-39). In several species of vertebrates, ACTH (1-13) amide undergoes end product modification to yield mono- and diacetylated forms ofα-MSH as major end products in the pars intermedia[1].
References

[1]. Dores RM, et al. Analysis of ACTH-related and CLIP-related peptides partially purified from the pituitary of the Australian lungfish, Neoceratodus forsteri. Gen Comp Endocrinol. 1990 Jul;79(1):64-73.

Density 1.49g/cm3
Molecular Formula C112H165N27O36
Molecular Weight 2465.67000
Exact Mass 2464.19000
PSA 1006.02000
LogP 1.91620
Index of Refraction 1.665
Storage condition -20℃
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport