ACTH (18-39) (human)

Modify Date: 2024-01-01 23:43:41

ACTH (18-39) (human) structure	Common Name	ACTH (18-39) (human)
	CAS Number	53917-42-3	Molecular Weight	2465.67000
	Density	1.49g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₁₂H₁₆₅N₂₇O₃₆	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of ACTH (18-39) (human)

Adrenocorticotropic Hormone (ACTH) (18-39), human is a corticotropinlike intermediate lobe peptide, which is is produced in the melanotrophs of the intermediate lobe of the pituitary.

Name	Adrenocorticotropic Hormone
Synonym	More Synonyms

Description	Adrenocorticotropic Hormone (ACTH) (18-39), human is a corticotropinlike intermediate lobe peptide, which is is produced in the melanotrophs of the intermediate lobe of the pituitary.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease Peptides
In Vitro	The ACTH family of polypeptides consists of ACTH(1-39) (adrenocorticotropin), ACTH (1-13)amide (α-melanotropin;α-MSH); and ACTH (18-39) (corticotropinlike intermediate lobe peptide, CLIP). These polypeptides are derived from a common precursor, proopiomelanocortin. In corticotropic cells of the pars distalis, proopiomelanocortin (POMC) undergoes a series of proteolytic cleavage reactions to yield ACTH (1-39) as a major end product. However, in the melanotropic cells of the pars intermedia, an additional set of proteolytic reactions results in the conversion of ACTH (1-39) to ACTH (1-13) amide and ACTH (18-39). In several species of vertebrates, ACTH (1-13) amide undergoes end product modification to yield mono- and diacetylated forms ofα-MSH as major end products in the pars intermedia[1].
References	[1]. Dores RM, et al. Analysis of ACTH-related and CLIP-related peptides partially purified from the pituitary of the Australian lungfish, Neoceratodus forsteri. Gen Comp Endocrinol. 1990 Jul;79(1):64-73.

Density	1.49g/cm3
Molecular Formula	C₁₁₂H₁₆₅N₂₇O₃₆
Molecular Weight	2465.67000
Exact Mass	2464.19000
PSA	1006.02000
LogP	1.91620
Index of Refraction	1.665
Storage condition	-20℃

ACTH (18-39) (human) MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport

Divergent paths for the selection of immunodominant epitopes from distinct antigenic sources.

Nat. Commun. 5 , 5369, (2014)

Immunodominant epitopes are few selected epitopes from complex antigens that initiate T-cell responses. Here to provide further insights into this process, we use a reductionist cell-free antigen-proc...

Macronutrient deprivation modulates antigen trafficking and immune recognition through HSC70 accessibility.

J. Immunol. 194(4) , 1446-53, (2015)

B lymphocytes exploit macroautophagy to capture cytoplasmic and nuclear proteins within autophagosomes. Fusion of autophagosomes with lysosomes and endosomes facilitates content proteolysis, with the ...

Enantioseparation of basic chiral compounds on a clindamycin phosphate-silica/zirconia hybrid monolith by capillary electrochromatography.

J. Chromatogr. A. 1356 , 289-93, (2014)

An organic-inorganic silica/zirconia hybrid monolithic capillary column was prepared by sol-gel process in a fused-silica capillary by using triethoxysilylpropylcarbamate (TEOSPC) derivative of clinda...

CLIP

ProteoMass™ ACTH Fragment 18-39 MALDI-MS

Adrenocorticotropic hormone fragment 18-39

ARG-PRO-VAL-LYS-VAL-TYR-PRO-ASN-GLY-ALA-GLU-ASP-GLU-SER-ALA-GLU-ALA-PHE-PRO-LEU-GLU-PHE: RPVKVYPNGAEDESAEAFPLEF

ACTH (18-39) (HUMAN)

Adrenocorticotropic Hormone (ACTH) (18-39), human