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65240-86-0

65240-86-0 structure
65240-86-0 structure
  • Name: PPM-18
  • Chemical Name: N-(1,4-dioxonaphthalen-2-yl)benzamide
  • CAS Number: 65240-86-0
  • Molecular Formula: C17H11NO3
  • Molecular Weight: 277.274
  • Catalog: Signaling Pathways Immunology/Inflammation NO Synthase
  • Create Date: 2018-06-15 17:24:36
  • Modify Date: 2024-01-03 17:45:14
  • PPM-18 (NSC 73233), a potent anti-inflammatory agent, inhibits nitric oxide synthase expression. PPM-18 is a potent inhibitor of iNOS expression by blocking the binding of NF-κB to promoter[1]. PPM-18, an analog of Vitamin K, induces autophagy and apoptosis in bladder cancer cells through ROS and AMPK signaling pathways[2].

Name N-(1,4-dioxonaphthalen-2-yl)benzamide
Synonyms Benzamide, N-(1,4-dihydro-1,4-dioxo-2-naphthalenyl)-
2-benzoylamino-1,4-naphthoquinone
ppm-18
N-(1,4-Dioxo-1,4-dihydro-2-naphthalenyl)benzamide
2-Benzamino-1,4-naphthochinon
Description PPM-18 (NSC 73233), a potent anti-inflammatory agent, inhibits nitric oxide synthase expression. PPM-18 is a potent inhibitor of iNOS expression by blocking the binding of NF-κB to promoter[1]. PPM-18, an analog of Vitamin K, induces autophagy and apoptosis in bladder cancer cells through ROS and AMPK signaling pathways[2].
Related Catalog
References

[1]. S M Yu, et al. Inhibition of nitric oxide synthase expression by PPM-18, a novel anti-inflammatory agent, in vitro and in vivo. Biochem J. 1997 Dec 1;328 ( Pt 2)(Pt 2):363-9.

[2]. Huiai Lu, et al. PPM-18, an Analog of Vitamin K, Induces Autophagy and Apoptosis in Bladder Cancer Cells Through ROS and AMPK Signaling Pathways. Front Pharmacol. 2021 Jul 9;12:684915.

Density 1.4±0.1 g/cm3
Boiling Point 517.5±50.0 °C at 760 mmHg
Molecular Formula C17H11NO3
Molecular Weight 277.274
Flash Point 208.2±30.3 °C
Exact Mass 277.073883
PSA 63.24000
LogP 2.09
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.667

~38%

65240-86-0 structure

65240-86-0

Literature: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT; CHOU, C., James; CHAN, Sherine, S.; RAHN, Jennifer, J.; JOSEY, Benjamin, J. Patent: WO2014/74976 A1, 2014 ; Location in patent: Paragraph 00239 ;

~%

65240-86-0 structure

65240-86-0

Literature: Josey, Benjamin J.; Inks, Elizabeth S.; Wen, Xuejun; Chou, C. James Journal of Medicinal Chemistry, 2013 , vol. 56, # 3 p. 1007 - 1022
Precursor  3

DownStream  0