Name | N-(1,4-dioxonaphthalen-2-yl)benzamide |
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Synonyms |
Benzamide, N-(1,4-dihydro-1,4-dioxo-2-naphthalenyl)-
2-benzoylamino-1,4-naphthoquinone ppm-18 N-(1,4-Dioxo-1,4-dihydro-2-naphthalenyl)benzamide 2-Benzamino-1,4-naphthochinon |
Description | PPM-18 (NSC 73233), a potent anti-inflammatory agent, inhibits nitric oxide synthase expression. PPM-18 is a potent inhibitor of iNOS expression by blocking the binding of NF-κB to promoter[1]. PPM-18, an analog of Vitamin K, induces autophagy and apoptosis in bladder cancer cells through ROS and AMPK signaling pathways[2]. |
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Related Catalog | |
References |
Density | 1.4±0.1 g/cm3 |
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Boiling Point | 517.5±50.0 °C at 760 mmHg |
Molecular Formula | C17H11NO3 |
Molecular Weight | 277.274 |
Flash Point | 208.2±30.3 °C |
Exact Mass | 277.073883 |
PSA | 63.24000 |
LogP | 2.09 |
Vapour Pressure | 0.0±1.3 mmHg at 25°C |
Index of Refraction | 1.667 |
~38% 65240-86-0 |
Literature: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT; CHOU, C., James; CHAN, Sherine, S.; RAHN, Jennifer, J.; JOSEY, Benjamin, J. Patent: WO2014/74976 A1, 2014 ; Location in patent: Paragraph 00239 ; |
~% 65240-86-0 |
Literature: Josey, Benjamin J.; Inks, Elizabeth S.; Wen, Xuejun; Chou, C. James Journal of Medicinal Chemistry, 2013 , vol. 56, # 3 p. 1007 - 1022 |