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130-15-4

130-15-4 structure

130-15-4 structure

Name: 1,4-naphthoquinone
Chemical Name: 1,4-naphthoquinone
CAS Number: 130-15-4
Molecular Formula: C₁₀H₆O₂
Molecular Weight: 158.153
Catalog: Chemical reagent Organic reagent Phenols
Create Date: 2018-06-23 20:58:46
Modify Date: 2026-06-30 16:48:22
1,4-Naphthoquinone is a potential pharmacophore for inhibition of both MAO (monoamine oxidase) and DNA topoisomerase activities, this latter associated with antitumor activity[1].

Name	1,4-naphthoquinone
Synonyms	para-naphthoquinone 1,4-naphthalene-dione ALPHA-NAPHTHOQUINONE 1,4-Naphthochinon 1,4-Naphthylquinone usafcy-10 1,4-Naphthoquinone ISO 9001：2015 REACH 1,4-Naphthoquinone, Standd α-Naphthoquinone 1,4-Naphthalenedione 1,4-Naphthochi 1,4-Hydronaphthoquinone 1,4-Naphthoquinone, (dry wt.), cont. up to water MFCD00001676 rcrawastenumberu166 Dapoxetine Impurity R 4-Naphthoquinone 1,4-napthaquinone,Naphthoquinone NAPHTHOQUINONE,1,4 Naphthalene-1,4-dione 1,4-naphthoquinone anion radical Rcra waste number U166 1,4-Naphthoquinone , >= (HPLC) 1,4-naphthoquinone (alpha) Naphthoquinone USAF cy-10 naphthoquinone 1,4-NAPHTHOQUINONE Hydronaphthoquinone 1,4-Naphthoquinone, contains up to water, R 1,4-naphtoquinone 1,4-DIOXONAPHTHALENE 1,4-Naphthoquinone,α-Naphthoquinone 1,4-Naphthoquinone, contains up to water α-Naphthoquinone NAPHTHOQUINONE,1,4-(RG) 1,4-Dihydronaphthalene-1,4-dione 1,4 napthaquinone 1,4-Naphthoquinone, dry weight, contains up to water 1,4-NAPHTHALENEDIONE 1,4-Naphthaquinone 1,4-NAPHTHOQUINOLINE NAPTHOQUINONE,1,4-(RG) 1,4-Naphthoquinone @100 μg/mL in Dichloromethane p-Naphthoquinone 1,4-Naphthalenedione нафтахинон, нафталин-1,4-дион, α-Naphthoquinone, п-нафтахинон, 1,4-Naphthoquinone, Naphthalene-1,4-dion 1,4-Naphthoquinone PA-NAPHTHOQUINONE 1,4-DIHYDRO-1,4-DIKETONAPHTHALENE 1,4-NaphthoquinoneSolution,1,000mg/L 1.4-Naphthoquinone [-4] 1,4-DIHYDRO-1,4-DIKETONAPHTHAL 1,4-Napthoquinone 1,4-Naphthoquinone,contains up to water EINECS 204-977-6 a-Naphthoquinone 1,4-Naftochinon naphthalene-1,4-dione A-NAPHTHOQUINONE 1,4-Naphthoquinone (dry wt.), cont. up to water 1,4-Naphthoquinone> 1,4-Naphthochinone

Description	1,4-Naphthoquinone is a potential pharmacophore for inhibition of both MAO (monoamine oxidase) and DNA topoisomerase activities, this latter associated with antitumor activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Coelho-Cerqueira E, et al. Beyond topoisomerase inhibition: antitumor 1,4-naphthoquinones as potential inhibitors of human monoamine oxidase. Chem Biol Drug Des. 2014 Apr;83(4):401-10.

Density	1.3±0.1 g/cm3
Boiling Point	297.9±40.0 °C at 760 mmHg
Melting Point	119-122 °C(lit.)
Molecular Formula	C₁₀H₆O₂
Molecular Weight	158.153
Flash Point	111.2±24.3 °C
Exact Mass	158.036774
PSA	34.14000
LogP	1.79
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.617
Stability	Stable. Incompatible with strong reducing agents, strong oxidizing agents.
Water Solubility	insoluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QL7175000

CHEMICAL NAME :: 1,4-Naphthoquinone

CAS REGISTRY NUMBER :: 130-15-4

LAST UPDATED :: 199801

DATA ITEMS CITED :: 21

MOLECULAR FORMULA :: C10-H6-O2

MOLECULAR WEIGHT :: 158.16

WISWESSER LINE NOTATION :: L66 BV EVJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 190 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 202 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5500 ug/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 133 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 72800 ug/kg/26W-I

TOXIC EFFECTS :: Liver - other changes Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6 gm/kg/30D-I

TOXIC EFFECTS :: Liver - liver function tests impaired Blood - methemoglobinemia-carboxyhemoglobin Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 mg/kg/10D-I

TOXIC EFFECTS :: Endocrine - changes in spleen weight Blood - pigmented or nucleated red blood cells Nutritional and Gross Metabolic - changes in iron

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1300 mg/kg/13W-I

TOXIC EFFECTS :: Endocrine - changes in spleen weight Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - changes in iron

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 72800 ug/kg/26W-I

TOXIC EFFECTS :: Liver - other changes Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg/29W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 5 mg/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - ovaries, fallopian tubes

MUTATION DATA

TYPE OF TEST :: Micronucleus test

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 100 ug/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 393,23,1997 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.1 mg/m3;Skin JAN 1993

Symbol	GHS06, GHS08, GHS09
Signal Word	Danger
Hazard Statements	H301-H315-H319-H330-H334-H335-H400
Precautionary Statements	P260-P273-P284-P301 + P310-P305 + P351 + P338-P310
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T+:Verytoxic;N:Dangerous for the environment;
Risk Phrases	R25;R26;R36/37/38;R43;R50
Safety Phrases	S26-S36/37-S45-S61-S38-S36/37/39-S28A-S24
RIDADR	UN 2811 6.1/PG 1
WGK Germany	3
RTECS	QL7175000
Packaging Group	I
Hazard Class	6.1
HS Code	29146910

Precursor 10
10075-62-4 84-85-5 571-60-8 91-20-3
90-15-3 119-64-2 2243-61-0 57857-70-2
2834-90-4 2216-69-5
DownStream 10
10273-60-6 55481-88-4 606-23-5 32588-54-8
59900-33-3 14422-78-7 143144-68-7 92-24-0
1785-52-0 92458-44-1

HS Code	2914690090
Summary	2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

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