Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Isochondrodendrine
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Purity: 95.0%
Stocking Period: 10 Day
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: ISOCHONDRODENDRINE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

477-62-3

477-62-3 structure

477-62-3 structure

Name: Isochondrodendrine
Chemical Name: Isochondrodendrine
CAS Number: 477-62-3
Molecular Formula: C₃₆H₃₈N₂O₆
Molecular Weight: 594.69700
Catalog: Research Areas Infection
Create Date: 2017-11-02 06:03:59
Modify Date: 2024-01-08 07:05:21
Isochondrodendrine ( Isochondrodendrin) is a class of bisbenzylisoquinoline alkaloid isolated from Isolona ghesquiereina. Isochondodendrine has strong antiplasmodial activity against Plasmodium falciparum[1].

Name	Isochondrodendrine
Synonyms	Isobebeerine d-Isochondodendrine Isochondodendrine Isochondodendrin Isobebeerin Isochondrodendrin O7,O7'-didemethyl-cycleanine O7,O7'-Didesmethyl-cycleanin 6,6'-dimethoxy-2,2'-dimethyl-cycleanane-7,7'-diol

Description	Isochondrodendrine ( Isochondrodendrin) is a class of bisbenzylisoquinoline alkaloid isolated from Isolona ghesquiereina. Isochondodendrine has strong antiplasmodial activity against Plasmodium falciparum[1].
Related Catalog	Research Areas >> Infection
Target	Plasmodium falciparum[1]
In Vivo	Isochondrodendrine has strong in vitro antiplasmodial activity against the chloroquine resistant strain FMC29 of Plasmodium falciparum. Toxicity observed is 50 to 100 fold greater towards Plasmodium falciparum than cultured L6 cells[1].
References	[1]. Mambu L, et al. Spectral characterisation and antiplasmodial activity of bisbenzylisoquinolines from Isolona ghesquiereina. Planta Med. 2000 Aug;66(6):537-40.

Density	1.239g/cm3
Boiling Point	689ºC at 760 mmHg
Molecular Formula	C₃₆H₃₈N₂O₆
Molecular Weight	594.69700
Flash Point	370.5ºC
Exact Mass	594.27300
PSA	83.86000
LogP	6.43220
Vapour Pressure	1.28E-19mmHg at 25°C
Index of Refraction	1.619

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GT8815000

CHEMICAL NAME :: Cycleanine, O(sup 7),O(sup 7')-didemethyl-

CAS REGISTRY NUMBER :: 477-62-3

LAST UPDATED :: 198411

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C36-H38-N2-O6

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1001 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 7,569,1949

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 371 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 7,569,1949

Precursor 0
DownStream 2
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