477-62-3

• 常用中文名：Isochondrodendrine
• 常用英文名：Isochondrodendrine
• CAS号：477-62-3
• 分子式：C₃₆H₃₈N₂O₆
• 分子量：594.69700
• 相关类别： 研究领域 感染
• 发布时间：2017-11-02 06:03:59
• 更新时间：2026-07-01 20:17:32
• Isochondrodendrine ( Isochondrodendrin) 是一类从 Isolona ghesquiereina 中分离出来的双苄基异喹啉生物碱。Isochondrodendrine 对 Plasmodium falciparum 具有很强的抗疟原虫活性。

名称

• 中文名: 异粒枝碱
• 英文名: Isochondrodendrine
• 中文别名: 羟基箭毒碱
• 英文别名: Isochondodendrine; O7,O7'-didemethyl-cycleanine; 8,11:20,23-Dietheno-1H,12H-[1,10]dioxacyclooctadecino[2,3,4-ij:11,12,13-i'j']diisoquinoline-6,18-diol, 2,3,12a,13,14,15,24,24a-octahydro-5,17-dimethoxy-1,13-dimethyl-, (12,24); Einecs -2; Isochondodendrin; Cycleanine, o(sup 7),o(sup 7')-didemethyl; D-Isochondodendrine; Isobebeerine; (1R,1'R)-2,2'-Dimethyl-6,6'-dimethoxy-7,18:11',18-diseco-8,18:12',18-dicyclotubocuran-7,7'-diol; 7-O,7'-O-Didemethylcycleanine; Cycleanine, o7,o7'-didemethyl- (9ci); O7,O7'-didemethylcycleanine; (+)-Isobebeerine; (R,R)-Isochondodendrine; 6,6'-dimethoxy-2,2'-dimethyl-cycleanane-7,7'-diol; D-Isochondrodendrine; d-Isochondodendrine; O7,O7'-Didesmethyl-cycleanin; Isobebeerin; Isochondrodendrin

物化性质

• 密度: 1.239g/cm3
• 沸点: 689ºC at 760 mmHg
• 分子式: C₃₆H₃₈N₂O₆
• 分子量: 594.69700
• 闪点: 370.5ºC
• 精确质量: 594.27300
• PSA: 83.86000
• LogP: 6.43220
• 蒸汽压: 1.28E-19mmHg at 25°C
• 折射率: 1.619

生物活性

• 描述: Isochondrodendrine ( Isochondrodendrin) 是一类从 Isolona ghesquiereina 中分离出来的双苄基异喹啉生物碱。Isochondrodendrine 对 Plasmodium falciparum 具有很强的抗疟原虫活性。
• 相关类别:
  研究领域 >> 感染
• 靶点:

  Plasmodium falciparum[1]

• 体内研究: Isochondrodendrine对恶性疟原虫的氯喹抗性菌株FMC29具有强烈的体外抗血浆活性。观察到的恶性疟原虫的毒性比培养的L6细胞高50至100倍[1]。
• 参考文献:

  [1]. Mambu L, et al. Spectral characterisation and antiplasmodial activity of bisbenzylisoquinolines from Isolona ghesquiereina. Planta Med. 2000 Aug;66(6):537-40.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : GT8815000 CHEMICAL NAME : Cycleanine, O(sup 7),O(sup 7')-didemethyl- CAS REGISTRY NUMBER : 477-62-3 LAST UPDATED : 198411 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C36-H38-N2-O6 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1001 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - respiratory depression REFERENCE : APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 7,569,1949 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 371 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - respiratory depression REFERENCE : APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 7,569,1949

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