Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2H-3-Benzoxacyclododecin-2,10(1H)-dione,4,5,6,7,8,9-hexahydro-11,13-dihydroxy-4-methyl-, (4S)-
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Purity: 98.0%
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10140-70-2

10140-70-2 structure

Name: Curvularin
Chemical Name: 2H-3-Benzoxacyclododecin-2,10(1H)-dione, 4,5,6,7,8,9-hexahydro-11,13-dihydroxy-4-methyl-, (-)
CAS Number: 10140-70-2
Molecular Formula: C₁₆H₂₀O₅
Molecular Weight: 292.32700
Catalog: Signaling Pathways Immunology/Inflammation NO Synthase
Create Date: 2018-08-04 11:00:49
Modify Date: 2025-08-25 18:05:47
Curvularin, a fungal metabolite and a potent mycotoxin naturally isolated from Curvularia lunata, inhibits cytokine-induced nitric oxide synthase (iNOS), with an IC50 of 9.5 µM[1][2].

Name	2H-3-Benzoxacyclododecin-2,10(1H)-dione, 4,5,6,7,8,9-hexahydro-11,13-dihydroxy-4-methyl-, (-)
Synonyms	curvularin

Description	Curvularin, a fungal metabolite and a potent mycotoxin naturally isolated from Curvularia lunata, inhibits cytokine-induced nitric oxide synthase (iNOS), with an IC50 of 9.5 µM[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Immunology/Inflammation >> NO Synthase
Target	IC50: 9.5 µM (iNOS)[2].
References	[1]. Kumar CG, et al. Metabolite profiling and biological activities of bioactive compounds produced by Chrysosporium lobatum strain BK-3 isolated from Kaziranga National Park, Assam, India. Springerplus. 2013 Dec;2(1):122. [2]. Yao Y, et al. Sporogen, S14-95, and S-curvularin, three inhibitors of human inducible nitric-oxide synthase expression isolated from fungi. Mol Pharmacol. 2003 Feb;63(2):383-91.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Hazard Codes	Xn
RIDADR	NONH for all modes of transport