Curvularin
Curvularin structure
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Common Name | Curvularin | ||
|---|---|---|---|---|
| CAS Number | 10140-70-2 | Molecular Weight | 292.32700 | |
| Density | 1.2g/cm3 | Boiling Point | 557ºC at 760mmHg | |
| Molecular Formula | C16H20O5 | Melting Point | 205-207 °C | |
| MSDS | Chinese USA | Flash Point | 207.9ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of CurvularinCurvularin, a fungal metabolite and a potent mycotoxin naturally isolated from Curvularia lunata, inhibits cytokine-induced nitric oxide synthase (iNOS), with an IC50 of 9.5 µM[1][2]. |
| Name | 2H-3-Benzoxacyclododecin-2,10(1H)-dione, 4,5,6,7,8,9-hexahydro-11,13-dihydroxy-4-methyl-, (-) |
|---|---|
| Synonym | More Synonyms |
| Description | Curvularin, a fungal metabolite and a potent mycotoxin naturally isolated from Curvularia lunata, inhibits cytokine-induced nitric oxide synthase (iNOS), with an IC50 of 9.5 µM[1][2]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 9.5 µM (iNOS)[2]. |
| References |
| Density | 1.2g/cm3 |
|---|---|
| Boiling Point | 557ºC at 760mmHg |
| Melting Point | 205-207 °C |
| Molecular Formula | C16H20O5 |
| Molecular Weight | 292.32700 |
| Flash Point | 207.9ºC |
| Exact Mass | 292.13100 |
| PSA | 83.83000 |
| LogP | 2.71880 |
| Vapour Pressure | 5.18E-13mmHg at 25°C |
| Index of Refraction | 1.54 |
| InChIKey | VDUIGYAPSXCJFC-JTQLQIEISA-N |
| SMILES | CC1CCCCCC(=O)c2c(O)cc(O)cc2CC(=O)O1 |
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Sulfur-containing cytotoxic curvularin macrolides from Penicillium sumatrense MA-92, a fungus obtained from the rhizosphere of the mangrove Lumnitzera racemosa.
J. Nat. Prod. 76(11) , 2145-9, (2013) Sumalarins A-C (1-3), the new and rare examples of sulfur-containing curvularin derivatives, along with three known analogues (4-6), were isolated and identified from the cytotoxic extract of Penicill... |
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Metabolite production by differentUlocladiumspecies
Int. J. Food Microbiol. 126(1-2) , 172-9, (2008) Ulocladium, which is phylogenetically related to Alternaria, contains species that are food spoilers and plant pathogens, but also species that have potential as enzyme producers and bio-control agent... |
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[Molecular basis of probes for cytoskeletal proteins].
Tanpakushitsu Kakusan Koso. 38(11) , 1730-41, (1993)
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Name: Inhibition of TGF-beta-induced human CTGF promoter activity transiently transfected i...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3404988
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Name: Antibacterial activity against Escherichia coli HB 101
Source: ChEMBL
Target: Escherichia coli
External Id: CHEMBL1017563
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Name: Antibacterial activity against Escherichia coli ATCC 25922
Source: ChEMBL
Target: Escherichia coli
External Id: CHEMBL1017562
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Name: Antibacterial activity against Staphylococcus aureus ATCC 25923
Source: ChEMBL
Target: Staphylococcus aureus
External Id: CHEMBL1017561
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Name: Antibacterial activity against Bacillus subtilis 168
Source: ChEMBL
Target: Bacillus subtilis
External Id: CHEMBL1017560
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Name: Binding affinity to (AGCCAGACA)9-MLP element (unknown origin) transiently transfected...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3406440
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| curvularin |