53501-41-0

53501-41-0 structure

Name: PIT-1
Chemical Name: N-[(3-chloro-2-hydroxy-5-nitrophenyl)carbamothioyl]benzamide
CAS Number: 53501-41-0
Molecular Formula: C₁₄H₁₀ClN₃O₄S
Molecular Weight: 351.765
Create Date: 2017-09-16 10:12:38
Modify Date: 2024-01-05 17:49:20
PIT-1 is a selective PIP3 (phosphatidylinositol 3,4,5-trisphosphate) antagonist. PIT-1 inhibits cancer cell survival and induces apoptosis by inhibition of PIP3 dependent PI3K / Akt signaling. PIT-1 exhibits antitumor activity in vivo[1].

Name	N-[(3-chloro-2-hydroxy-5-nitrophenyl)carbamothioyl]benzamide
Synonyms	Benzamide, N-[[(3-chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]- N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]-benzamide PIT-1 Impentamine dihydrobromide N-[(3-Chloro-2-hydroxy-5-nitrophenyl)carbamothioyl]benzamide

Description	PIT-1 is a selective PIP3 (phosphatidylinositol 3,4,5-trisphosphate) antagonist. PIT-1 inhibits cancer cell survival and induces apoptosis by inhibition of PIP3 dependent PI3K / Akt signaling. PIT-1 exhibits antitumor activity in vivo[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
References	[1]. Miao B, et al. Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains. Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20126-31.