PIT-1

Modify Date: 2024-01-05 17:49:20

PIT-1 structure	Common Name	PIT-1
	CAS Number	53501-41-0	Molecular Weight	351.765
	Density	1.6±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₄H₁₀ClN₃O₄S	Melting Point	N/A
	MSDS	USA	Flash Point	N/A
	Symbol	GHS07, GHS09	Signal Word	Warning

Use of PIT-1

PIT-1 is a selective PIP3 (phosphatidylinositol 3,4,5-trisphosphate) antagonist. PIT-1 inhibits cancer cell survival and induces apoptosis by inhibition of PIP3 dependent PI3K / Akt signaling. PIT-1 exhibits antitumor activity in vivo[1].

Name	N-[(3-chloro-2-hydroxy-5-nitrophenyl)carbamothioyl]benzamide
Synonym	More Synonyms

Description	PIT-1 is a selective PIP3 (phosphatidylinositol 3,4,5-trisphosphate) antagonist. PIT-1 inhibits cancer cell survival and induces apoptosis by inhibition of PIP3 dependent PI3K / Akt signaling. PIT-1 exhibits antitumor activity in vivo[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
References	[1]. Miao B, et al. Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains. Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20126-31.

Density	1.6±0.1 g/cm3
Molecular Formula	C₁₄H₁₀ClN₃O₄S
Molecular Weight	351.765
Exact Mass	351.008057
PSA	139.27000
LogP	4.28
Index of Refraction	1.747

Symbol	GHS07, GHS09
Signal Word	Warning
Hazard Statements	H302-H400
Precautionary Statements	P273
RIDADR	UN 3077 9 / PGIII

Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains.

Proc. Natl. Acad. Sci. U. S. A. 107(46) , 20126-31, (2010)

The PI3-kinase (PI3K) pathway regulates many cellular processes, especially cell metabolism, cell survival, and apoptosis. Phosphatidylinositol-3,4,5-trisphosphate (PIP3), the product of PI3K activity...

Inhibition of cell migration by PITENINs: the role of ARF6.

Oncogene 31(39) , 4317-32, (2012)

We have reported previously the development of small-molecule phosphatidylinositol-3,4,5-trisphosphate (PIP3) antagonists (PITs) that block pleckstrin homology (PH) domain interaction, including activ...

Benzamide, N-[[(3-chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]-

N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]-benzamide

PIT-1

Impentamine dihydrobromide

N-[(3-Chloro-2-hydroxy-5-nitrophenyl)carbamothioyl]benzamide