1268720-28-0

1268720-28-0 structure

Name: Maresin 1
Chemical Name: 7(R)-Maresin 1
CAS Number: 1268720-28-0
Molecular Formula: C₂₂H₃₂O₄
Molecular Weight: 360.487
Catalog: Research Areas Inflammation/Immunology
Create Date: 2016-09-08 15:35:27
Modify Date: 2024-01-04 13:33:06
Maresin 1, produced by human Mφs from endogenous docosahexaenoic acid (DHA) and a specialized proresolving mediator, stimulates intracellular [Ca2+] and secretion. Maresin 1 possesses anti-inflammatory activity[1][2][3].

Name	7(R)-Maresin 1
Synonyms	7(R)-Maresin 1 quinolin-7-ol 7-hydroxychinoline (4Z,7R,8E,10E,12Z,14S,16Z,19Z)-7,14-Dihydroxy-4,8,10,12,16,19-docosahexaenoic acid 7-Chinolinol 7R,14S-dihydroxydocosa-4Z,8E,10E,12Z,16Z,19Z-hexaenoic acid 4,8,10,12,16,19-Docosahexaenoic acid, 7,14-dihydroxy-, (4Z,7R,8E,10E,12Z,14S,16Z,19Z)- 7-Quinolinol 7-HYDROXYQUINOLINE 7R-maresin-1 7-hydoxyquinoline Maresin 1

Description	Maresin 1, produced by human Mφs from endogenous docosahexaenoic acid (DHA) and a specialized proresolving mediator, stimulates intracellular [Ca2+] and secretion. Maresin 1 possesses anti-inflammatory activity[1][2][3].
Related Catalog	Research Areas >> Inflammation/Immunology
In Vitro	Maresin 1 (MaR1, 300 nM) reduces neutrophil migration and reactive oxygen species production, besides decreasing IL-1b, TNF-a, IL-6, and INF-g production[3]. Cell Viability Assay[3] Cell Line: Neutrophils (2 ╳105 cells/well). Concentration: 300 nM. Incubation Time: 30 min. Result: Adherent cells are stimulated for 24 h with LPS (1 mg/ml) in the presence or absence of MaR1 (300 nM) in a final volume of 250 ml/well[3].
In Vivo	Maresin 1 (MaR1) dose-dependently inhibits TRPV1 currents in neurons, blocks capsaicin (100 nM)-induced inward currents (IC50=0.49 nM), and reduces both inflammation- and chemotherapy-induced neuropathic pain in mice[2]. Maresin 1 (MaR1, 0.1, 0.3, and 1 μg/animal, e.v.) protects mice against acute DSS-induced colitis. Maresin 1 (0.3, and 1 μg/animal, e.v.) treatment markedly reduces macroscopic damage in the acute protocol of DSS-induced colitis[3]. Animal Model: Male CD1 mice (8-10 wk of age) (colitis was induced by DSS)[3]. Dosage: 0.1, 0.3, and 1 μg/animal. Administration: Intraocular route once a day from day 0 to day 7. Result: MaR1 (0.3 and 1 mg/animal) significantly reduces MPO levels in mouse colon tissue.
References	[1]. Markus V Olsen, et al. Maresin 1, a Specialized Proresolving Mediator, Stimulates Intracellular [Ca 2+ ] and Secretion in Conjunctival Goblet Cells. J Cell Physiol. 2020 Jun 8. [2]. Macrophage Proresolving Mediator Maresin 1 Stimulates Tissue Regeneration and Controls Pain [3]. Rodrigo Marcon, et al. Maresin 1, a Proresolving Lipid Mediator Derived From omega-3 Polyunsaturated Fatty Acids, Exerts Protective Actions in Murine Models of Colitis. J Immunol. 2013 Oct 15;191(8):4288-98.

Density	1.0±0.1 g/cm3
Boiling Point	559.4±50.0 °C at 760 mmHg
Molecular Formula	C₂₂H₃₂O₄
Molecular Weight	360.487
Flash Point	306.2±26.6 °C
Exact Mass	360.230072
PSA	77.76000
LogP	3.81
Vapour Pressure	0.0±3.4 mmHg at 25°C
Index of Refraction	1.546

Precursor 5
1391043-18-7 21944-83-2 53046-97-2 1391043-08-5
1391043-11-0
DownStream 0

1268720-28-0	1268720-66-6
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1158522-08-7	940364-43-2
134104-43-1	131615-57-1
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1396747-95-7	1018584-77-4
1375289-11-4	849349-65-1