1268720-28-0
1268720-28-0 structure
- Name: Maresin 1
- Chemical Name: 7(R)-Maresin 1
- CAS Number: 1268720-28-0
- Molecular Formula: C22H32O4
- Molecular Weight: 360.487
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2016-09-08 15:35:27
- Modify Date: 2024-01-04 13:33:06
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Maresin 1, produced by human Mφs from endogenous docosahexaenoic acid (DHA) and a specialized proresolving mediator, stimulates intracellular [Ca2+] and secretion. Maresin 1 possesses anti-inflammatory activity[1][2][3].
| Name | 7(R)-Maresin 1 |
|---|---|
| Synonyms |
7(R)-Maresin 1
quinolin-7-ol 7-hydroxychinoline (4Z,7R,8E,10E,12Z,14S,16Z,19Z)-7,14-Dihydroxy-4,8,10,12,16,19-docosahexaenoic acid 7-Chinolinol 7R,14S-dihydroxydocosa-4Z,8E,10E,12Z,16Z,19Z-hexaenoic acid 4,8,10,12,16,19-Docosahexaenoic acid, 7,14-dihydroxy-, (4Z,7R,8E,10E,12Z,14S,16Z,19Z)- 7-Quinolinol 7-HYDROXYQUINOLINE 7R-maresin-1 7-hydoxyquinoline Maresin 1 |
| Description | Maresin 1, produced by human Mφs from endogenous docosahexaenoic acid (DHA) and a specialized proresolving mediator, stimulates intracellular [Ca2+] and secretion. Maresin 1 possesses anti-inflammatory activity[1][2][3]. |
|---|---|
| Related Catalog | |
| In Vitro | Maresin 1 (MaR1, 300 nM) reduces neutrophil migration and reactive oxygen species production, besides decreasing IL-1b, TNF-a, IL-6, and INF-g production[3]. Cell Viability Assay[3] Cell Line: Neutrophils (2 ╳105 cells/well). Concentration: 300 nM. Incubation Time: 30 min. Result: Adherent cells are stimulated for 24 h with LPS (1 mg/ml) in the presence or absence of MaR1 (300 nM) in a final volume of 250 ml/well[3]. |
| In Vivo | Maresin 1 (MaR1) dose-dependently inhibits TRPV1 currents in neurons, blocks capsaicin (100 nM)-induced inward currents (IC50=0.49 nM), and reduces both inflammation- and chemotherapy-induced neuropathic pain in mice[2]. Maresin 1 (MaR1, 0.1, 0.3, and 1 μg/animal, e.v.) protects mice against acute DSS-induced colitis. Maresin 1 (0.3, and 1 μg/animal, e.v.) treatment markedly reduces macroscopic damage in the acute protocol of DSS-induced colitis[3]. Animal Model: Male CD1 mice (8-10 wk of age) (colitis was induced by DSS)[3]. Dosage: 0.1, 0.3, and 1 μg/animal. Administration: Intraocular route once a day from day 0 to day 7. Result: MaR1 (0.3 and 1 mg/animal) significantly reduces MPO levels in mouse colon tissue. |
| References |
[2]. Macrophage Proresolving Mediator Maresin 1 Stimulates Tissue Regeneration and Controls Pain |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 559.4±50.0 °C at 760 mmHg |
| Molecular Formula | C22H32O4 |
| Molecular Weight | 360.487 |
| Flash Point | 306.2±26.6 °C |
| Exact Mass | 360.230072 |
| PSA | 77.76000 |
| LogP | 3.81 |
| Vapour Pressure | 0.0±3.4 mmHg at 25°C |
| Index of Refraction | 1.546 |
| Precursor 5 | |
|---|---|
| DownStream 0 | |
