Maresin 1
Modify Date: 2024-01-04 13:33:06
Maresin 1 structure
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Common Name | Maresin 1 | ||
|---|---|---|---|---|
| CAS Number | 1268720-28-0 | Molecular Weight | 360.487 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 559.4±50.0 °C at 760 mmHg | |
| Molecular Formula | C22H32O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 306.2±26.6 °C | |
Use of Maresin 1Maresin 1, produced by human Mφs from endogenous docosahexaenoic acid (DHA) and a specialized proresolving mediator, stimulates intracellular [Ca2+] and secretion. Maresin 1 possesses anti-inflammatory activity[1][2][3]. |
| Name | 7(R)-Maresin 1 |
|---|---|
| Synonym | More Synonyms |
| Description | Maresin 1, produced by human Mφs from endogenous docosahexaenoic acid (DHA) and a specialized proresolving mediator, stimulates intracellular [Ca2+] and secretion. Maresin 1 possesses anti-inflammatory activity[1][2][3]. |
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| Related Catalog | |
| In Vitro | Maresin 1 (MaR1, 300 nM) reduces neutrophil migration and reactive oxygen species production, besides decreasing IL-1b, TNF-a, IL-6, and INF-g production[3]. Cell Viability Assay[3] Cell Line: Neutrophils (2 ╳105 cells/well). Concentration: 300 nM. Incubation Time: 30 min. Result: Adherent cells are stimulated for 24 h with LPS (1 mg/ml) in the presence or absence of MaR1 (300 nM) in a final volume of 250 ml/well[3]. |
| In Vivo | Maresin 1 (MaR1) dose-dependently inhibits TRPV1 currents in neurons, blocks capsaicin (100 nM)-induced inward currents (IC50=0.49 nM), and reduces both inflammation- and chemotherapy-induced neuropathic pain in mice[2]. Maresin 1 (MaR1, 0.1, 0.3, and 1 μg/animal, e.v.) protects mice against acute DSS-induced colitis. Maresin 1 (0.3, and 1 μg/animal, e.v.) treatment markedly reduces macroscopic damage in the acute protocol of DSS-induced colitis[3]. Animal Model: Male CD1 mice (8-10 wk of age) (colitis was induced by DSS)[3]. Dosage: 0.1, 0.3, and 1 μg/animal. Administration: Intraocular route once a day from day 0 to day 7. Result: MaR1 (0.3 and 1 mg/animal) significantly reduces MPO levels in mouse colon tissue. |
| References |
[2]. Macrophage Proresolving Mediator Maresin 1 Stimulates Tissue Regeneration and Controls Pain |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 559.4±50.0 °C at 760 mmHg |
| Molecular Formula | C22H32O4 |
| Molecular Weight | 360.487 |
| Flash Point | 306.2±26.6 °C |
| Exact Mass | 360.230072 |
| PSA | 77.76000 |
| LogP | 3.81 |
| Vapour Pressure | 0.0±3.4 mmHg at 25°C |
| Index of Refraction | 1.546 |
CAS#:1391043-18-7
CAS#:21944-83-2
CAS#:53046-97-2
CAS#:1391043-08-5
CAS#:1391043-11-0| 7(R)-Maresin 1 |
| quinolin-7-ol |
| 7-hydroxychinoline |
| (4Z,7R,8E,10E,12Z,14S,16Z,19Z)-7,14-Dihydroxy-4,8,10,12,16,19-docosahexaenoic acid |
| 7-Chinolinol |
| 7R,14S-dihydroxydocosa-4Z,8E,10E,12Z,16Z,19Z-hexaenoic acid |
| 4,8,10,12,16,19-Docosahexaenoic acid, 7,14-dihydroxy-, (4Z,7R,8E,10E,12Z,14S,16Z,19Z)- |
| 7-Quinolinol |
| 7-HYDROXYQUINOLINE |
| 7R-maresin-1 |
| 7-hydoxyquinoline |
| Maresin 1 |