29809-15-2

29809-15-2 structure
29809-15-2 structure
  • Name: Meconin-d3
  • Chemical Name: 6-methoxy-7-(trideuteriomethoxy)-3H-2-benzofuran-1-one
  • CAS Number: 29809-15-2
  • Molecular Formula: C10H7D3O4
  • Molecular Weight: 197.202
  • Catalog: Research Areas Metabolic Disease
  • Create Date: 2017-06-24 05:48:38
  • Modify Date: 2024-01-03 18:27:23
  • Meconin-d3 is the deuterium labeled Meconine. Meconine is an endogenous metabolite[1][2].

Name 6-methoxy-7-(trideuteriomethoxy)-3H-2-benzofuran-1-one
Synonyms Meconin-d3
1(3H)-Isobenzofuranone, 6-methoxy-7-(methyl-d-oxy)-
Meconic Lactone-d3
Opianyl-d3
6-Methoxy-7-[(H)methyloxy]-2-benzofuran-1(3H)-one
6,7-Dimethoxyphthalide-d3
Description Meconin-d3 is the deuterium labeled Meconine. Meconine is an endogenous metabolite[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Jones JT, et al. Detection of codeine, morphine, 6-monoacetylmorphine, and meconin in human umbilical cord tissue: method validation and evidence of in utero heroin exposure. Ther Drug Monit. 2015;37(1):45-52.

[2]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

Density 1.3±0.1 g/cm3
Boiling Point 404.2±45.0 °C at 760 mmHg
Molecular Formula C10H7D3O4
Molecular Weight 197.202
Flash Point 185.1±28.8 °C
Exact Mass 197.076736
PSA 44.76000
LogP 0.63
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.548