146510-36-3

146510-36-3 structure

Name: Olanexidine
Chemical Name: 1-carbamimidoyl-2-[(3,4-dichlorophenyl)methyl]-1-octylguanidine
CAS Number: 146510-36-3
Molecular Formula: C₁₇H₂₇Cl₂N₅
Molecular Weight: 372.33600
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-07-22 18:35:41
Modify Date: 2024-01-04 22:59:40
Olanexidine is an antibacterial agent. Olanexidine is active against a wide range of bacteria, imcluding both Gram-positive and Gram-negative bacteria Olanexidine is also an antiseptic. Olanexidine can be used in the research of infection and inflammation[1][2][3].

Name	1-carbamimidoyl-2-[(3,4-dichlorophenyl)methyl]-1-octylguanidine
Synonyms	Olanexidine N1-(3,4-Dichlorobenzyl)-N5-octylbiguanide Imidodicarbonimidicdiamide,N-[(3,4-dichlorophenyl)methyl]-N'-octyl

Description	Olanexidine is an antibacterial agent. Olanexidine is active against a wide range of bacteria, imcluding both Gram-positive and Gram-negative bacteria Olanexidine is also an antiseptic. Olanexidine can be used in the research of infection and inflammation[1][2][3].
Related Catalog	Research Areas >> Infection Research Areas >> Inflammation/Immunology Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Olanexidine (50 μM, 48 h) exhibits broad-spectrum bactericidal activity against Gram-positive cocci and Gram-negative bacteria[1]. Olanexidine (50 μg/mL, 24 h) inhibits chronic inflammatory reactions in oral mucosal cells[2]. Olanexidine (Olanexidine gluconate, 0-15000 μg/mL) inhibits the binding ability of virus-like particles to the binding receptor of human norovirus and increases the aggregation of virus-like particles[3]. Cell Viability Assay[1] Cell Line: Gram-positive cocci, Enterococcus spp., Gram-positive bacilli, Gram-negative strains Concentration: 0-1 mg/mL approximately Incubation Time: 30 s Result: Inhibited bacterial activity with MIC values ranging from 6.8 to 1740 μg/mL approximately.
In Vivo	Olanexidine (1 -2% in saline, applied to the skin) is active against transient or resident bacterial flora on the skin of male cynomolgus monkeys[4]. Animal Model: Male cynomolgus monkeys[4] Dosage: 1 %, 1.5%, 2% in saline Administration: Applied to the skin Result: Showed the fast-acting and long-lasting bactericidal effects at 1.5% concentration.