1011301-27-1

1011301-27-1 structure

Name: Tenovin-3
Chemical Name: N-[(4-aminophenyl)carbamothioyl]-4-tert-butylbenzamide
CAS Number: 1011301-27-1
Molecular Formula: C₁₈H₂₁N₃OS
Molecular Weight: 327.444
Catalog: Signaling Pathways Apoptosis MDM-2/p53
Create Date: 2018-11-14 21:14:38
Modify Date: 2026-07-08 12:14:49
Tenovin-3 is able to increase p53 levels, determined in MCF-7 cells treated for 6 hr at 10 μM.Target: p53in vitro: Tenovins inhibit the activities of human SirT1 and SirT2, two members of the NAD+-dependent class III histone deacetylases that also belong to the sirtuin family.[1]

Name	N-[(4-aminophenyl)carbamothioyl]-4-tert-butylbenzamide
Synonyms	QC-514 1-(4-amino-phenyl)-3-(4-tert-butyl-benzoyl)-thiourea Tenovin 3,MDM-2/p53,Inhibitor,Tenovin-3,inhibit N-(4-aMinophenylcbaMothioyl)-4-tert-butylbenzaMide N-[(4-aminophenyl)-carbamothioyl]-4-tert-butyl-benzamide Tenovin-3 ，S2176 N-[[(4-Aminophenyl)amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide TENOVIN-3 1-(4-Amino-phenyl)-3-(4-tert-butyl-benzoyl)-thiourea Tenovin-3, >= N-[(4-Aminophenyl)carbamothioyl]-4-(2-methyl-2-propanyl)benzamide 1-(4-Amino-phenyl)-3-(4-tert-butyl-benzoyl)-thiourea Benzamide, N-[[(4-aminophenyl)amino]thioxomethyl]-4-(1,1-dimethylethyl) TENOVIN 3;TENOVIN3 Tenovin-3, 10 mM in DMSO

Description	Tenovin-3 is able to increase p53 levels, determined in MCF-7 cells treated for 6 hr at 10 μM.Target: p53in vitro: Tenovins inhibit the activities of human SirT1 and SirT2, two members of the NAD+-dependent class III histone deacetylases that also belong to the sirtuin family.[1]
Related Catalog	Signaling Pathways >> Apoptosis >> MDM-2/p53 Research Areas >> Cancer
References	[1]. Lain S, et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008 May;13(5):454-63.