1414-39-7

1414-39-7 structure

Name: albomycin
Chemical Name: albomycin δ1
CAS Number: 1414-39-7
Molecular Formula: C₃₆H₅₈FeN₁₀O₁₈S
Molecular Weight: 1006.81000
Catalog: API Antibiotics Macrolide drug
Create Date: 2018-07-10 17:02:43
Modify Date: 2024-01-17 02:17:09
Albomycin is an inhibitor of aminoacyl-tRNA synthetases with Trojan-horse effect. Albomycin is delivered by iron-chelator portion into bacterial through ferrichrome-specific transporter system. Albomycin combats against a wide range of Gram-positive and Gram-negative bacteria. Albomycin also serves as an efficient iron-scavenger of producer[1].

Name	albomycin δ1
Synonyms	ferric 2-[[2-[[5-(acetyl-hydroxy-amino)-2-[[5-(acetyl-hydroxy-ami no)-2-[[5-(acetyl-hydroxy-amino)-2-amino-pentanoyl]amino]pentanoy l]amino]pentanoyl]amino]-3-hydroxy-propanoyl]amino]-3-[(2R,3S,4R, 5R)-3,4-dihydroxy-5-(3-methyl-2,4-dioxo albomycin delta1

Description	Albomycin is an inhibitor of aminoacyl-tRNA synthetases with Trojan-horse effect. Albomycin is delivered by iron-chelator portion into bacterial through ferrichrome-specific transporter system. Albomycin combats against a wide range of Gram-positive and Gram-negative bacteria. Albomycin also serves as an efficient iron-scavenger of producer[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Albomycin 也与 FhuA 结合，与高铁色素竞争结合位点。FhuA 是埋在大肠杆菌外膜的 β 桶。或者，Albomycin 结合 FhuD，FhuD 是细胞膜 ABC 转运蛋白 FhuB/FhuC 的质周亚基[1]。 Albomycin 对肺炎链球菌的生长有明显的抑制作用，最低抑制浓度为 4-62 nM[1]。
References	[1]. Travin DY, et al. Natural Trojan horse inhibitors of aminoacyl-tRNA synthetases. RSC Chem Biol. 2021 Feb 22;2(2):468-485.