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1114544-31-8

1114544-31-8 structure
1114544-31-8 structure
  • Name: Ponatinib hydrochloride
  • Chemical Name: 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide,hydrochloride
  • CAS Number: 1114544-31-8
  • Molecular Formula: C29H28ClF3N6O
  • Molecular Weight: 569.02
  • Catalog: Signaling Pathways Autophagy Autophagy
  • Create Date: 2018-08-27 11:47:54
  • Modify Date: 2025-08-26 17:08:53
  • Ponatinib (AP24534) hydrochloride is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively[1].

Name 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide,hydrochloride
Synonyms 3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl}benzamide hydrochloride (1:1)
Benzamide, 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-, hydrochloride (1:1)
Iclusig (TN)
UNII-96R6PU3D8J
Ponatinib hydrochloride (USAN)
AP 24534 hydrochloride
Ponatinib hydrochloride
96R6PU3D8J
Ponatinib HCl
Description Ponatinib (AP24534) hydrochloride is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively[1].
Related Catalog
Target

VEGFR2:1.5 nM (IC50)

FGFR1:2.2 nM (IC50)

PDGFRα:1.1 nM (IC50)

Abl:0.37 nM (IC50)

LYN:0.24 nM (IC50)

Src:5.4 nM (IC50)

References

[1]. O'Hare T, et al. AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell, 2009, 16(5), 401-412.

Molecular Formula C29H28ClF3N6O
Molecular Weight 569.02
Exact Mass 568.196533
PSA 65.77000
LogP 5.20680
Hazard Codes Xn
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