Name | 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide,hydrochloride |
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Synonyms |
3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl}benzamide hydrochloride (1:1)
Benzamide, 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-, hydrochloride (1:1) Iclusig (TN) UNII-96R6PU3D8J Ponatinib hydrochloride (USAN) AP 24534 hydrochloride Ponatinib hydrochloride 96R6PU3D8J Ponatinib HCl |
Description | Ponatinib (AP24534) hydrochloride is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively[1]. |
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Related Catalog | |
Target |
VEGFR2:1.5 nM (IC50) FGFR1:2.2 nM (IC50) PDGFRα:1.1 nM (IC50) Abl:0.37 nM (IC50) LYN:0.24 nM (IC50) Src:5.4 nM (IC50) |
References |
Molecular Formula | C29H28ClF3N6O |
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Molecular Weight | 569.02 |
Exact Mass | 568.196533 |
PSA | 65.77000 |
LogP | 5.20680 |
Hazard Codes | Xn |
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