RWJ 50271

Modify Date: 2024-01-16 13:43:03

RWJ 50271 structure	Common Name	RWJ 50271
	CAS Number	162112-37-0	Molecular Weight	410.41
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₁₇F₃N₄O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of RWJ 50271

RWJ 50271 is an selective inhibitor of lymphocyte function-associated antigen-1/intercellular adhesion molecule-1(LFA-1/ICAM-1) interaction with an IC50 of 5.0 μM (HL60 cells)[1].

Name	N-(3-Hydroxypropyl)-5-methyl-1-{4-[3-(trifluoromethyl)phenyl]-1,3 -thiazol-2-yl}-1H-pyrazole-4-carboxamide

Description	RWJ 50271 is an selective inhibitor of lymphocyte function-associated antigen-1/intercellular adhesion molecule-1(LFA-1/ICAM-1) interaction with an IC50 of 5.0 μM (HL60 cells)[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Cytoskeleton >> Integrin
Target	IC50: 5.0 μM (LFA-1/ICAM-1, HL60 cells)[1]
References	[1]. Sanfilippo PJ, et al. Novel thiazole based heterocycles as inhibitors of LFA-1/ICAM-1 mediated cell adhesion. J Med Chem. 1995 Mar 31;38(7):1057-9.

Molecular Formula	C₁₈H₁₇F₃N₄O₂S
Molecular Weight	410.41
Exact Mass	410.10200
PSA	111.77000
LogP	4.01000