171596-36-4

171596-36-4 structure

Name: Nortadalafil
Chemical Name: Nortadalafil
CAS Number: 171596-36-4
Molecular Formula: C₂₁H₁₇N₃O₄
Molecular Weight: 375.377
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
Create Date: 2017-12-27 13:54:16
Modify Date: 2024-01-02 18:24:28
Nortadalafil is demethyl Tadalafil, which is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED) under the name Cialis; and under the name Adcirca for the treatment of pulmonary arterial hypertension.IC50 value:Target:

Name	Nortadalafil
Synonyms	Pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione, 6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-, (6R,12aR)- CS-0823 N-Desmethyl Tadalafil (6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione Tadalafil Impurity 21

Description	Nortadalafil is demethyl Tadalafil, which is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED) under the name Cialis; and under the name Adcirca for the treatment of pulmonary arterial hypertension.IC50 value:Target:
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Cardiovascular Disease
References	[1]. Beghyn, et al. PDE5 inhibitors: An original access to novel potent arylated analogues of tadalafil. Bioorganic & Medicinal Chemistry Letters (2007), 17(3), 789-792. [2]. Daugan, et al. The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogue. Journal of Medicinal Chemistry (2003), 46(21), 4533-4542. [3]. Porst H, et al. Chronic PDE-5 inhibition in patients with erectile dysfunction - a treatment approach using tadalafil once-daily. Expert Opin Pharmacother. 2012 Jul;13(10):1481-94. [4]. Frey MK, Lang I. Tadalafil for the treatment of pulmonary arterial hypertension. Expert Opin Pharmacother. 2012 Apr;13(5):747-55.

171489-59-1

~70%

171596-36-4

Literature: Beghyn, Terence; Hounsou, Candide; Deprez, Benoit P. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 3 p. 789 - 792

171596-41-1

171596-36-4

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 3 p. 789 - 792

4299-70-1

171596-36-4

Literature: Journal of Medicinal Chemistry, , vol. 46, # 21 p. 4533 - 4542

120-57-0

171596-36-4

Literature: Journal of Medicinal Chemistry, , vol. 46, # 21 p. 4533 - 4542

14907-27-8

171596-36-4

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 3 p. 789 - 792