Nortadalafil

Modify Date: 2025-08-20 18:20:33

Nortadalafil structure	Common Name	Nortadalafil
	CAS Number	171596-36-4	Molecular Weight	375.377
	Density	1.6±0.1 g/cm3	Boiling Point	718.6±60.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₁₇N₃O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	388.4±32.9 °C

Use of Nortadalafil

Nortadalafil is demethyl Tadalafil, which is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED) under the name Cialis; and under the name Adcirca for the treatment of pulmonary arterial hypertension.IC50 value:Target:

Name	Nortadalafil
Synonym	More Synonyms

Description	Nortadalafil is demethyl Tadalafil, which is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED) under the name Cialis; and under the name Adcirca for the treatment of pulmonary arterial hypertension.IC50 value:Target:
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Cardiovascular Disease
References	[1]. Beghyn, et al. PDE5 inhibitors: An original access to novel potent arylated analogues of tadalafil. Bioorganic & Medicinal Chemistry Letters (2007), 17(3), 789-792. [2]. Daugan, et al. The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogue. Journal of Medicinal Chemistry (2003), 46(21), 4533-4542. [3]. Porst H, et al. Chronic PDE-5 inhibition in patients with erectile dysfunction - a treatment approach using tadalafil once-daily. Expert Opin Pharmacother. 2012 Jul;13(10):1481-94. [4]. Frey MK, Lang I. Tadalafil for the treatment of pulmonary arterial hypertension. Expert Opin Pharmacother. 2012 Apr;13(5):747-55.

Description

Related Catalog

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)

Research Areas >> Cardiovascular Disease

References

[1]. Beghyn, et al. PDE5 inhibitors: An original access to novel potent arylated analogues of tadalafil. Bioorganic & Medicinal Chemistry Letters (2007), 17(3), 789-792.

[2]. Daugan, et al. The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogue. Journal of Medicinal Chemistry (2003), 46(21), 4533-4542.

[3]. Porst H, et al. Chronic PDE-5 inhibition in patients with erectile dysfunction - a treatment approach using tadalafil once-daily. Expert Opin Pharmacother. 2012 Jul;13(10):1481-94.

[4]. Frey MK, Lang I. Tadalafil for the treatment of pulmonary arterial hypertension. Expert Opin Pharmacother. 2012 Apr;13(5):747-55.

Density	1.6±0.1 g/cm3
Boiling Point	718.6±60.0 °C at 760 mmHg
Molecular Formula	C₂₁H₁₇N₃O₄
Molecular Weight	375.377
Flash Point	388.4±32.9 °C
Exact Mass	375.121918
PSA	87.15000
LogP	0.38
Vapour Pressure	0.0±2.3 mmHg at 25°C
Index of Refraction	1.772
Storage condition	2-8C

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Literature: Beghyn, Terence; Hounsou, Candide; Deprez, Benoit P. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 3 p. 789 - 792

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H-D-Trp-OMe.HCl

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Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 3 p. 789 - 792

Pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione, 6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-, (6R,12aR)-

CS-0823

N-Desmethyl Tadalafil

(6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione

Tadalafil Impurity 21

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Nortadalafil

Use of Nortadalafil

Names

Nortadalafil Biological Activity

Chemical & Physical Properties

Synthetic Route

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.