763903-67-9

763903-67-9 structure

Name: FOSALVUDINE TIDOXIL
Chemical Name: (2-decoxy-3-dodecylsulfanylpropyl) [(2R,3S,5R)-3-fluoro-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl hydrogen phosphate
CAS Number: 763903-67-9
Molecular Formula: C₃₅H₆₄FN₂O₈PS
Molecular Weight: 722.93
Create Date: 2016-12-22 17:42:28
Modify Date: 2024-01-03 16:37:28
Fosalvudine tidoxil is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Fosalvudine tidoxil is a prodrug derived from Alovudine (HY-B1516). Fosalvudine tidoxil is less toxic than Alovudine and can be used for the research of HIV-1 infection[1].

Name	(2-decoxy-3-dodecylsulfanylpropyl) [(2R,3S,5R)-3-fluoro-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl hydrogen phosphate
Synonyms	Fosalvudine tidoxil Fosalvudine HDP 99.0003

Description	Fosalvudine tidoxil is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Fosalvudine tidoxil is a prodrug derived from Alovudine (HY-B1516). Fosalvudine tidoxil is less toxic than Alovudine and can be used for the research of HIV-1 infection[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Signaling Pathways >> Anti-infection >> Reverse Transcriptase
Target	Nucleoside reverse transcriptase[1]
In Vivo	Fosalvudine tidoxil (15-100 mg/kg/day; oral; 8 weeks) 对大鼠产生显著的线粒体肝毒性[1]。 Animal Model: Sprague-Dawley rats[1] Dosage: 15, 40, or 100 mg/kg/day Administration: Oral gavage, 8 weeks Result: Induced significant mtDNA depletion. At doses of 15, 40, and 100 mg/kg, the mean hepatic mtDNA values were 62, 64, and 47% of control values, respectively.
References	[1]. Venhoff AC, et al. Mitochondrial DNA depletion in rat liver induced by fosalvudine tidoxil, a novel nucleoside reverse transcriptase inhibitor prodrug. Antimicrob Agents Chemother. 2009 Jul;53(7):2748-51.