501948-05-6
501948-05-6 structure
- Name: Rosabulin
- Chemical Name: 2-[3-[(4-cyanophenyl)methyl]indolizin-1-yl]-N-(3-methyl-1,2-thiazol-5-yl)-2-oxoacetamide
- CAS Number: 501948-05-6
- Molecular Formula: C22H16N4O2S
- Molecular Weight: 400.45300
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Microtubule/Tubulin
- Create Date: 2018-03-15 08:00:00
- Modify Date: 2024-01-10 10:59:22
-
Rosabulin is a potent microtubule inhibitor, with anti-cancer activities.
| Name | 2-[3-[(4-cyanophenyl)methyl]indolizin-1-yl]-N-(3-methyl-1,2-thiazol-5-yl)-2-oxoacetamide |
|---|---|
| Synonyms |
UNII-6Z674O12T6
Rosabulin I01-9450 STA-5312 |
| Description | Rosabulin is a potent microtubule inhibitor, with anti-cancer activities. |
|---|---|
| Related Catalog | |
| In Vitro | Rosabulin demonstrates substantial anti-proliferative activity against a wide range of cancer cell linesin vitro, with IC50 values extending down into the nanomolar range. Rosabulin is inhibition of microtubule assembly and subsequent arrest of the cell cycle. Rosabulin is active against several tumor cell lines that express moderate to high levels of P-glycoprotein (Pgp), including lines insensitive to Taxol, Vincristine, and Adriamycin in which Pgp activity is a major contributor to the MDR phenotype[1]. |
| In Vivo | Rosabulin has shown in vivo activity in several murine tumors as well as human tumor xenograft models, including drug resistant tumors[1]. |
| References |
| Density | 1.34 |
|---|---|
| Melting Point | 233ºC |
| Molecular Formula | C22H16N4O2S |
| Molecular Weight | 400.45300 |
| Exact Mass | 400.09900 |
| PSA | 115.50000 |
| LogP | 4.06108 |
| Index of Refraction | 1.7 |
| Storage condition | 2-8℃ |
| HS Code | 2934999090 |
|---|
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |