Rosabulin

Modify Date: 2024-01-10 10:59:22

Rosabulin Structure
Rosabulin structure
 Common Name Rosabulin
CAS Number 501948-05-6 Molecular Weight 400.45300
Density 1.34 Boiling Point N/A
Molecular Formula C22H16N4O2S Melting Point 233ºC
MSDS N/A Flash Point N/A

 Use of Rosabulin


Rosabulin is a potent microtubule inhibitor, with anti-cancer activities.

 Names

Name 2-[3-[(4-cyanophenyl)methyl]indolizin-1-yl]-N-(3-methyl-1,2-thiazol-5-yl)-2-oxoacetamide
Synonym More Synonyms

 Rosabulin Biological Activity

Description Rosabulin is a potent microtubule inhibitor, with anti-cancer activities.
Related Catalog
In Vitro Rosabulin demonstrates substantial anti-proliferative activity against a wide range of cancer cell linesin vitro, with IC50 values extending down into the nanomolar range. Rosabulin is inhibition of microtubule assembly and subsequent arrest of the cell cycle. Rosabulin is active against several tumor cell lines that express moderate to high levels of P-glycoprotein (Pgp), including lines insensitive to Taxol, Vincristine, and Adriamycin in which Pgp activity is a major contributor to the MDR phenotype[1].
In Vivo Rosabulin has shown in vivo activity in several murine tumors as well as human tumor xenograft models, including drug resistant tumors[1].
References

[1]. Keizo Koya, et al. STA-5312, a novel tubulin inhibitor, demonstrates the anti-cancer activity against chemotherapy-resistant cancers. Proc Amer Assoc Cancer Res, Volume 45, 2004

 Chemical & Physical Properties

Density 1.34
Melting Point 233ºC
Molecular Formula C22H16N4O2S
Molecular Weight 400.45300
Exact Mass 400.09900
PSA 115.50000
LogP 4.06108
Index of Refraction 1.7
Storage condition 2-8℃

 Safety Information

HS Code 2934999090

 Synthetic Route

3-Methylisothiazol-5-amine structure

3-Methylisothia...

CAS#:24340-76-9

Oxalyl chloride structure

Oxalyl chloride

CAS#:79-37-8

4-(indolizin-3-ylmethyl)benzonitrile structure

4-(indolizin-3-...

CAS#:501948-43-2

~78%

Rosabulin Structure

Rosabulin

CAS#:501948-05-6

Literature: SBR Pharmaceuticals Corp. Patent: US2003/153759 A1, 2003 ;
p-Tolunitrile structure

p-Tolunitrile

CAS#:104-85-8

~%

Rosabulin Structure

Rosabulin

CAS#:501948-05-6

Literature: Li, Hao; Xia, Zhiqiang; Chen, Shoujun; Koya, Keizo; Ono, Mitsunori; Sun, Lijun Organic Process Research and Development, 2007 , vol. 11, # 2 p. 246 - 250
4-(4-pyridin-2-ylbut-3-ynyl)benzonitrile structure

4-(4-pyridin-2-...

CAS#:501948-45-4

~%

Rosabulin Structure

Rosabulin

CAS#:501948-05-6

Literature: Li, Hao; Xia, Zhiqiang; Chen, Shoujun; Koya, Keizo; Ono, Mitsunori; Sun, Lijun Organic Process Research and Development, 2007 , vol. 11, # 2 p. 246 - 250
4-(indolizin-3-ylmethyl)benzonitrile structure

4-(indolizin-3-...

CAS#:501948-43-2

~%

Rosabulin Structure

Rosabulin

CAS#:501948-05-6

Literature: Li, Hao; Xia, Zhiqiang; Chen, Shoujun; Koya, Keizo; Ono, Mitsunori; Sun, Lijun Organic Process Research and Development, 2007 , vol. 11, # 2 p. 246 - 250
4-(indolizine-3-carbonyl)benzonitrile structure

4-(indolizine-3...

CAS#:501948-42-1

~%

Rosabulin Structure

Rosabulin

CAS#:501948-05-6

Literature: Li, Hao; Xia, Zhiqiang; Chen, Shoujun; Koya, Keizo; Ono, Mitsunori; Sun, Lijun Organic Process Research and Development, 2007 , vol. 11, # 2 p. 246 - 250
P-CYANOACETOPHENONE structure

P-CYANOACETOPHENONE

CAS#:1443-80-7

~%

Rosabulin Structure

Rosabulin

CAS#:501948-05-6

Literature: Li, Hao; Xia, Zhiqiang; Chen, Shoujun; Koya, Keizo; Ono, Mitsunori; Sun, Lijun Organic Process Research and Development, 2007 , vol. 11, # 2 p. 246 - 250
2-picoline structure

2-picoline

CAS#:109-06-8

~%

Rosabulin Structure

Rosabulin

CAS#:501948-05-6

Literature: Li, Hao; Xia, Zhiqiang; Chen, Shoujun; Koya, Keizo; Ono, Mitsunori; Sun, Lijun Organic Process Research and Development, 2007 , vol. 11, # 2 p. 246 - 250

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

UNII-6Z674O12T6
Rosabulin
I01-9450
STA-5312
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1314667-27-0
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
930439-75-1
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1018584-77-4
Chemsrc provides Rosabulin(CAS#:501948-05-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Rosabulin are included as well.>> amp version: Rosabulin

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