54863-37-5
54863-37-5 structure
- Name: Dapansutrile
- Chemical Name: 3-(Methylsulfonyl)propanenitrile
- CAS Number: 54863-37-5
- Molecular Formula: C4H7NO2S
- Molecular Weight: 133.17
- Catalog: Signaling Pathways Immunology/Inflammation NOD-like Receptor (NLR)
- Create Date: 2017-01-01 18:32:48
- Modify Date: 2024-01-09 00:16:37
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Dapansutrile (OLT1177) is a potent, selective and orally active inhibitor of NLRP3 inflammasome. Anti-inflammatory, analgesic activity[1].
| Name | 3-(Methylsulfonyl)propanenitrile |
|---|---|
| Synonyms |
2-methyl-2H-isoindole-1-carbonitrile
2H-Isoindole-1-carbonitrile,2-methyl 1-cyano-2-methylisoindole 3-methanesulfonylpropionitrile 3-(methylsulfonyl)propionitrile 1-cyano-2-methylsulphonylethane |
| Description | Dapansutrile (OLT1177) is a potent, selective and orally active inhibitor of NLRP3 inflammasome. Anti-inflammatory, analgesic activity[1]. |
|---|---|
| Related Catalog | |
| Target |
NLRP3 inflammasome[1] |
| References |
| Molecular Formula | C4H7NO2S |
|---|---|
| Molecular Weight | 133.17 |
| Exact Mass | 133.02000 |
| PSA | 66.31000 |
| LogP | 1.02548 |
| Storage condition | 2-8℃ |
|
~%
54863-37-5 |
| Literature: Kjaer et al. Acta Chemica Scandinavica (1947-1973), 1953 , vol. 7, p. 1370,1373 |
|
~88%
54863-37-5 |
| Literature: OLATEC INDUSTRIES LLC; ST. LAURENT, Joseph P.; JONES, Gerald S.; BRESSE, David M. Patent: US2013/225865 A1, 2013 ; Location in patent: Paragraph 0056-0058 ; |
|
~94%
54863-37-5 |
| Literature: Bell, Richard; Cottam, Peter D.; Davies, John; Jones, D. Neville Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , # 7 p. 2106 - 2115 |
|
~%
54863-37-5 |
| Literature: Rao, B. Dharma; Sarathi, T.V.N. Partha; Annapurna; Vani Journal of Sulfur Chemistry, 2011 , vol. 32, # 3 p. 263 - 272 |
