26766-35-8

26766-35-8 structure

Name: LY43578
Chemical Name: bis(4-chlorophenyl)-pyrimidin-5-ylmethanol
CAS Number: 26766-35-8
Molecular Formula: C₁₇H₁₂Cl₂N₂O
Molecular Weight: 331.20
Catalog: Signaling Pathways Metabolic Enzyme/Protease Cytochrome P450
Create Date: 2016-11-20 13:26:59
Modify Date: 2024-02-05 23:03:38
LY43578 is an orally active aromatase inhibitor. LY43578 inhibits P-450-dependent p-nitroanisole O-demethylation and ethylmorphine N-demethylation in hepatic microsomes isolated from rat, with the IC50 of 0.3 and 5 μΜ, respectively. LY43578 can be used for neurological disorder study[1][2].

Name	bis(4-chlorophenyl)-pyrimidin-5-ylmethanol
Synonyms	bis(4-chlorophenyl)(pyrimidin-5-yl) methanol Bis(4-chlorophenyl)(5-pyrimidinyl)methanol

Description	LY43578 is an orally active aromatase inhibitor. LY43578 inhibits P-450-dependent p-nitroanisole O-demethylation and ethylmorphine N-demethylation in hepatic microsomes isolated from rat, with the IC50 of 0.3 and 5 μΜ, respectively. LY43578 can be used for neurological disorder study[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase
References	[1]. Lindstrom TD, et al. Disposition of the aromatase inhibitor LY56110 and associated induction and inhibition studies in rats, dogs, and monkeys. Fundam Appl Toxicol. 1987;8(4):595-604. [2]. Gonzalez MI, et al. Injection of an aromatase inhibitor after the critical period of sexual differentiation. Pharmacol Biochem Behav. 1994;47(1):183-186.

4595-59-9

90-98-2

~53%

26766-35-8