26766-37-0

26766-37-0 structure

Name: LY56110
Chemical Name: 5-[bis(4-chlorophenyl)methyl]pyrimidine
CAS Number: 26766-37-0
Molecular Formula: C₁₇H₁₂Cl₂N₂
Molecular Weight: 315.20
Catalog: Signaling Pathways Metabolic Enzyme/Protease Cytochrome P450
Create Date: 2016-09-14 12:52:25
Modify Date: 2025-09-12 13:24:30
LY56110 is an orally active aromatase inhibitor. LY56110 inhibits P-450-dependent p-nitroanisole O-demethylation and ethylmorphine N-demethylation in hepatic microsomes isolated from rat, with the IC50 of 2.5 and 11 μΜ, respectively. LY56110 can be used for neurological disorder study[1][2].

Name	5-[bis(4-chlorophenyl)methyl]pyrimidine
Synonyms	5-[(4-chlorophenyl)(4-chlorophenyl)methyl]pyrimidine 5-(Bis(4-chlorophenyl)methyl)pyrimidine

Description	LY56110 is an orally active aromatase inhibitor. LY56110 inhibits P-450-dependent p-nitroanisole O-demethylation and ethylmorphine N-demethylation in hepatic microsomes isolated from rat, with the IC50 of 2.5 and 11 μΜ, respectively. LY56110 can be used for neurological disorder study[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease
References	[1]. Lindstrom TD, et al. Disposition of the aromatase inhibitor LY56110 and associated induction and inhibition studies in rats, dogs, and monkeys. Fundam Appl Toxicol. 1987;8(4):595-604. [2]. O'Neill LA, et al. Effect of estrogen inhibitors on conceptus estrogen synthesis and development in the gilt. Domest Anim Endocrinol. 1991;8(1):139-153.

Density	1.296g/cm3
Boiling Point	438.3ºC at 760mmHg
Molecular Formula	C₁₇H₁₂Cl₂N₂
Molecular Weight	315.20
Flash Point	251.5ºC
Exact Mass	314.03800
PSA	25.78000
LogP	4.96360
Vapour Pressure	1.79E-07mmHg at 25°C
Index of Refraction	1.625

26766-35-8

~54%

26766-37-0

Literature: Keenan, Martine; Abbott, Michael J.; Alexander, Paul W.; Armstrong, Tanya; Best, Wayne M.; Berven, Bradley; Botero, Adriana; Chaplin, Jason H.; Charman, Susan A.; Chatelain, Eric; Von Geldern, Thomas W.; Kerfoot, Maria; Khong, Andrea; Nguyen, Tien; McManus, Joshua D.; Morizzi, Julia; Ryan, Eileen; Scandale, Ivan; Thompson, R. Andrew; Wang, Sen Z.; White, Karen L. Journal of Medicinal Chemistry, 2012 , vol. 55, # 9 p. 4189 - 4204

26766-35-8

~26%

26766-37-0

108395-11-5

108395-10-4

Literature: Taylor, Harold M.; Jones, C. David; Davenport, James D.; Hirsch, Kenneth S.; Kress, T.J.; Weaver, Dix Journal of Medicinal Chemistry, 1987 , vol. 30, # 8 p. 1359 - 1365

90-98-2

26766-37-0

Precursor 2
26766-35-8 90-98-2
DownStream 0

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