1048039-15-1
1048039-15-1 structure
- Name: COR 170
- Chemical Name: N-(adamant-1-yl)-4-oxo-1-pentyl-6-phenyl-1,4-dihydroquinoline-3-carboxamide
- CAS Number: 1048039-15-1
- Molecular Formula: C31H36N2O2
- Molecular Weight: 468.63000
- Catalog: Signaling Pathways GPCR/G Protein Cannabinoid Receptor
- Create Date: 2017-08-12 19:48:46
- Modify Date: 2024-01-29 09:46:46
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COR170 (11u) is a selective CB2 inverse-agonist which is a 4-quinolone-3-carboxylic acid derivative with a Ki value of 3.8 nM for CB2 receptor. COR170 can be used for the research of inflammation and neuroprotection[1][2][3].
| Name | N-(adamant-1-yl)-4-oxo-1-pentyl-6-phenyl-1,4-dihydroquinoline-3-carboxamide |
|---|
| Description | COR170 (11u) is a selective CB2 inverse-agonist which is a 4-quinolone-3-carboxylic acid derivative with a Ki value of 3.8 nM for CB2 receptor. COR170 can be used for the research of inflammation and neuroprotection[1][2][3]. |
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| Related Catalog | |
| In Vitro | COR170 (11u) (0-1 μM) inhibits CB2 receptor in HEK cell membranes[2]. Cell Viability Assay[2] Cell Line: HEK cells Concentration: 0-1 μM Incubation Time: Result: Possessed a Ki value of 3.8 nM for CB2 receptor in HEK cell membranes. |
| In Vivo | COR170 (11u) (1.5-6 mg/kg; i.p, once) reduces the late phase nociceptive behaviour induced by formalin[3]. Animal Model: Mice with formalin (1.25%, 30 μl) injections[3] Dosage: 1.5, 3 and 6 mg/kg Administration: Intraperitoneal injection; 1.5, 3 and 6 mg/kg for once Result: Reduced the late phase nociceptive behaviour induced by formalin with a 6 mg/kg dose and 10 min before formalin and abolished the analgesic effect from GW405833 which is a CB2<>sub receptor partial agonist. |
| References |
| Molecular Formula | C31H36N2O2 |
|---|---|
| Molecular Weight | 468.63000 |
| Exact Mass | 468.27800 |
| PSA | 51.10000 |
| LogP | 6.94820 |