Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (+)-Griseofulvin
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: griseofulvin
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson
Email: info@tianfuchem.com

126-07-8

126-07-8 structure

Name: Griseofulvin
Chemical Name: griseofulvin
CAS Number: 126-07-8
Molecular Formula: C₁₇H₁₇ClO₆
Molecular Weight: 352.766
Catalog: API Antibiotics Other antibiotics
Create Date: 2018-02-04 08:00:00
Modify Date: 2026-06-30 16:59:57
Griseofulvin(Gris-PEG; Grifulvin) is a spirocyclic fungal natural product used in treatment of fungal dermatophytes; Antifungal drug.

Name	griseofulvin
Synonyms	Spiro[benzofuran-2(3H),1'-cyclohexene]-3,4'-dione, 7-chloro-2',4,6-trimethoxy-6'-methyl-, (2S-trans) Fulvidex spiro(benzofuran-2(3h),1’-cyclohexene)-3,4’-dione,7-chloro-2’4,6-trimethoxy isovi spiro(benzofuran-2(3h),1’-cyclohexene)-3,4’-dione,7-chloro-2’,4,6-trimetho Spiro[benzofuran-2(3H),1'-cyclohexene]-3,4'-dione, 7-chloro-2',4,6-trimethoxy-6'beta-methyl idifulvin ISEOFULVIN,MICRONIZED iseofulvin mirconized iseofulvin (micronized) (+)-ISEOFULVIN (+)-Griseofulvin iseofulvin, (2S)-trans-7-Chloro-2μ,4,6-trimethoxy-6μ-methylspiro(benzofuran-2[3H],1μ-cyclohexene)-3,4μ-dione 7-Chloro-2,4,6-trimethoxy-6-methyl-, (1S-trans)-Spiro(benzofuran-2(3H),1-cyclohexene)-3,4-dione Grisactin Grizeofulvin 7-Chloro-2',4,6-trimethoxy-6'β-methylspiro[benzofuran-2(3H),1'-cyclohexene]-3,4'-dione MFCD00082343 Polygris iseofulvin Permeability Diameter Curling factor iseofulvin I1D406992ug/mg(ai) (2S,6'R)-7-Chloro-2',4,6-triMethoxy-6'-Methyl-3H-spiro[1-benzofuran-2,1'-cyclohexan]-2'-ene-3,4'-dione Murfulvin iseofulvin ifulvin, Fulcin) Griseofulvin Permeability Diameter isovinfp ISEOFULVIN(RG) Spirofulvin Likunden 7-Chloro-2',4,6-trimethoxy-6'b-methylspiro[benzofuran-2(3H),1'-cyclohexene]-3,4'-dione (1'S,6'R)-7-Chloro-2',4,6-trimethoxy-6'-methyl-spiro[benzofuran-2(3H),1'-cyclohexene]-3,4'-dione UNII-32HRV3E3D5 isefulin (2S,6'R)-7-Chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione Spiro[benzofuran-2(3H),1'-cyclohexene]-3,4'-dione, 7-chloro-2',4,6-trimethoxy-6'b-methyl- (8CI) Sporostatin xan Lamoryl Fulvicin ISEOFULVIN, ACTIVE Spirobenzofuran-2(3H),cyclohexene-3,4-dione, 7-chloro-2,4,6-trimethoxy-6-methyl-, (1S,6R) izeofulvin Polyis Likuden (2S)-TRANS-7-CHLORO-2',4,6-TRIMETHOXY-6'-METHYLSPIRO(BENZOFURAN-2[3H],1'-CYCLOHEXENE)-3,4'-DIONE (1’S,6’R)-7-chloro-2’,4,6-trimethoxy-6’-methylspiro[benzofuran-2(3H),1’-[2]cyclohexene]-3,4’-dione (1'S-trans)-7-Chloro-2',4,6-trimethoxy-6'-methylspiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione iseofulvin 0 [2S-TRANS]-7-CHLORO-2,4,6-TRIMETHOXY-6'-METHYLSPIRO[BENZOFURAN-2(3H), 1'-CYCLOHEXANE]-3,4'-DIONE 7-chloro-4,6-dimethoxycoumaran-3-one-2-spiro-1’-(2’-methoxy-6’-methylcyclohex-2’-en-4’-one) Neo-Fulcin Spiro[benzofuran-2(3H),1'-cyclohexene]-3,4'-dione, 7-chloro-2',4,6-trimethoxy-6'-methyl-, (1'S-trans) nsc34533 Sporostatin isact (2S,5'R)-7-chloro-3',4,6-trimethoxy-5'-methylspiro[1-benzofuran-2,4'-cyclohex-2-ene]-1',3-dione iseofulvin Solution, 100ppm Grifulvin Fulcin Poncyl FP amudane Fulvicin Bolus AMudane, isovin, Curling factor, icin, ifulvin, isactin, Fulcin, Norofulvin, Likuden, Idifulvin NSC Guservin iseofulvin (1’S-trans)- 7-chloro-2’,4,6-trimethoxy-6’-methylspiro[benzofuran-2(3H),1’-cyclohex-2’-ene]-3,4’-dione Grisovin EINECS 204-767-4 Poncyl is-peg ysio ISEOFULVIN,MICRONIZED,BP iffonia simplicifolia seeds

Description	Griseofulvin(Gris-PEG; Grifulvin) is a spirocyclic fungal natural product used in treatment of fungal dermatophytes; Antifungal drug.
Related Catalog	Signaling Pathways >> Anti-infection >> Fungal Research Areas >> Infection

Density	1.4±0.1 g/cm3
Boiling Point	570.4±50.0 °C at 760 mmHg
Melting Point	218-220 °C(lit.)
Molecular Formula	C₁₇H₁₇ClO₆
Molecular Weight	352.766
Flash Point	228.0±29.1 °C
Exact Mass	352.071381
PSA	71.06000
LogP	3.53
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.583
Water Solubility	practically insoluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WG9800000

CHEMICAL NAME :: Spiro(benzofuran-2(3H),1'-(2)cyclohexene)-3,4'-dione, 7-chloro-2'4,6-trimethoxy-6'-beta- methyl-

CAS REGISTRY NUMBER :: 126-07-8

BEILSTEIN REFERENCE NO. :: 0095226

LAST UPDATED :: 199801

DATA ITEMS CITED :: 53

MOLECULAR FORMULA :: C17-H17-Cl-O6

MOLECULAR WEIGHT :: 352.79

WISWESSER LINE NOTATION :: T56 BOXVJ FO1 HO1 IG C-& DL6V DX BUTJ CO1 E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Blood - changes in cell count (unspecified) Blood - changes in bone marrow (not otherwise specified)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >50 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >12 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 280 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 109 gm/kg/52W-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 462 gm/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Blood - lymphoma, including Hodgkin's disease

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 440 gm/kg/52W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 120 mg/kg/49W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 730 gm/kg/52W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1250 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2 gm/kg

SEX/DURATION :: female 11-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - urogenital system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 12500 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 500 mg/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - eye/ear

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 10 gm/kg

SEX/DURATION :: female 8-9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1 gm/kg

SEX/DURATION :: female 48-52 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: DNA repair

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sister chromatid exchange

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Sperm Morphology

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Bird - chicken Fibroblast

DOSE/DURATION :: 50 mg/L

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 253,361,1975 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,391,1987 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 7,391,1987 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW LLOYA2 Lloydia. (Cincinnati, OH) V.1-41, 1938-78. For publisher information, see JNPRDF. Volume(issue)/page/year: 38,21,1975 TOXICOLOGY REVIEW 32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York, Springer, 1975 Volume(issue)/page/year: -,49,1975 TOXICOLOGY REVIEW ARMIAZ Annual Review of Microbiology. (Annual Reviews, Inc., POB 10139, Palo Alto, CA 94303) V.1- 1947- Volume(issue)/page/year: 26,279,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3685 No. of Facilities: 58 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1656 (estimated) No. of Female Employees: 774 (estimated)

Symbol	GHS07, GHS08
Signal Word	Danger
Hazard Statements	H317-H351-H360
Precautionary Statements	P201-P280-P308 + P313
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T:Toxic
Risk Phrases	R60;R61;R40;R43
Safety Phrases	S53-S22-S36/37/39-S45
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	WG9800000

Precursor 5
186581-53-3 136616-32-5 18113-21-8 81325-85-1
136734-91-3
DownStream 6
3209-13-0 3187-20-0 3573-90-8 1158186-19-6
126-07-8 611-68-7

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1479918-25-6	933728-67-7
1565592-33-7	1250379-79-3
1248139-95-8	1093092-08-0
1226407-92-6	1203684-92-7
1344922-38-8	1432061-01-2