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Product Name: Potassium canrenoate
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2181-04-6

2181-04-6 structure

Name: Potassium canrenoate
Chemical Name: Canrenoic Acid Potassium Salt
CAS Number: 2181-04-6
Molecular Formula: C₂₂H₂₉KO₄
Molecular Weight: 396.56200
Catalog: Signaling Pathways Metabolic Enzyme/Protease Mineralocorticoid Receptor
Create Date: 2018-07-05 19:22:34
Modify Date: 2026-07-12 18:00:49
Canrenoate (Aldadiene) potassium, a prodrug that releases canrenone, is a potent, competitive mineralocorticoid receptor (aldosterone receptor) antagonist. Potassium canrenoate, as a diuretic, is used for the research of hypertension[1][2][3].

Name	Canrenoic Acid Potassium Salt
Synonyms	POTASSIUM CANRENOATE canrenoic acid potassium 17-HYDROXY-3-OXOPREGNA-4,6-DIENE-21-CBOXYLIC ACID Canrenoic acid potassium salt competitive,inhibit,hypertension,diuretic,SC-14266,fibrosis,Mineralocorticoid Rector,Canrenoate potassium,SC14266,Inhibitor,Canrenoate,Aldadiene,cdiac,SC (17α)-17-Hydroxy-3-oxopregna-4,6-diene-21-cboxylic Acid PotassiuM Salt EINECS 218-554-9 PotassiuM 17-Hydroxy-3-oxo-17α-pregna-4,6-diene-21-cboxylate Potassium canrenoate (jp15) Soldactone MF 465 a Soldactone (tn) Canrenoic acid potassium salt powder Potassium canrenoate 17-Hydroxy-3-oxopregna-4,6-diene-21-cboxylic acid potassium salt Canrenoate potassium (usan) D01943 CanrenoicAcidPotassiumSal PotassiuM Aldadiene 17a-Pregna-4,6-diene-21-cboxylic acid, 17-hydroxy-3-oxo-, potassium salt (7CI) Soldactona Kanrenol 4,6-ANDROSTADIEN-17ALPHA-YL-PROPIONIC ACID-17BETA-OL-3-ONE POTASSIUM SALT Venactone PotassiuM 3-(3-oxo-17β-hydroxy-4,6-androstadien-17α-yl)propionate 17-Hydroxy-3-oxo-17a-pregna-4,6-diene-21-cboxylic acid potassium salt Canrenone, potassium salt Canrenoate MFCD05662375 canrenone potassium Pregna-4,6-diene-21-cboxylic acid, 17-hydroxy-3-oxo-, monopotassium salt, (17a)- (9CI) PotassiuM β-(3-Oxo-17β-hydroxyandrosta-4,6-dien-17α-yl) Propionate 17-Hydroxy-3-oxopregna-4,6-diene-21-cboxylic acid, Potassium canrenoate PotassiuM 3-(17β-Hydroxy-3-oxoandrosta-4,6-dien-17-yl)propionate Cabrenoic Acid Potassium Salt Soludactone SC 14266 17a-Pregna-4,6-diene-21-cboxylic acid, 17-hydroxy-3-oxo-, monopotassium salt (8CI) CANRENOIC ACID POTASSIUM SALT 17-Hydroxy-3-oxopregna-4,6-diene-21-carboxylic acid,Potassium canrenoate Free acid potassium salt 17-HYDROXY-3-OXOPREGNA-4,6-DIENE-21-CBOXYLIC ACID POTASSIUM SALT Potassium kaneliate

Description	Canrenoate (Aldadiene) potassium, a prodrug that releases canrenone, is a potent, competitive mineralocorticoid receptor (aldosterone receptor) antagonist. Potassium canrenoate, as a diuretic, is used for the research of hypertension[1][2][3].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Mineralocorticoid Receptor
In Vivo	Potassium canrenoate has been shown to cause in rats a dose-dependent increase in myelogenous leukemia and statistically significant increases in malignant tumor of the liver, thyroid, brain and mammary gland[2][3]. Potassium canrenoate (20 mg/kg/day; drinking water) reduces isoprenaline-induced cardiac fibrosis in the rat[4].
References	[1]. Iqbal J, Andrew R, et al. Displacement of cortisol from human heart by acute administration of a mineralocorticoid receptor antagonist. J Clin Endocrinol Metab. 2014;99(3):915-922.

Molecular Formula	C₂₂H₂₉KO₄
Molecular Weight	396.56200
Exact Mass	396.17000
PSA	77.43000
LogP	2.55550
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU3500000

CHEMICAL NAME :: 17-alpha-Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, monopotassium salt

CAS REGISTRY NUMBER :: 2181-04-6

LAST UPDATED :: 199512

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C22-H30-O4.K

MOLECULAR WEIGHT :: 397.62

WISWESSER LINE NOTATION :: L E5 B666 OV KU MUTJ A1 E1 FQ F2VQ &-KA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 650 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 183 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 112 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 740 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 140 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 165 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 gm/kg/30D-I

TOXIC EFFECTS :: Behavioral - tremor Lungs, Thorax, or Respiration - respiratory stimulation Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 14560 mg/kg/26W-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1350 mg/kg/30D-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition Endocrine - changes in adrenal weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 560 mg/kg

SEX/DURATION :: female 7-13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 420 mg/kg

SEX/DURATION :: female 7-13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Rodent - mouse Lymphocyte

DOSE/DURATION :: 150 mg/L

REFERENCE :: ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 61,201,1988

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R22
Safety Phrases	S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	TU3500000
HS Code	2916209090

HS Code	2916209090
Summary	2916209090 other cyclanic, cyclenic or cyclotherpenic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

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