Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 5-Fluorouridine
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 5-Fluorouridine
Price: ￥348.0/5g
Purity: 98.0%
Stocking Period: 1 Day
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 5-Fluorouridine
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316-46-1

316-46-1 structure

Name: 5-Fluorouridine
Chemical Name: 5-fluorouridine
CAS Number: 316-46-1
Molecular Formula: C₉H₁₁FN₂O₆
Molecular Weight: 262.192
Catalog: Biochemical Nucleoside drugs Nucleoside intermediate
Create Date: 2018-06-17 18:00:41
Modify Date: 2024-01-02 09:46:04
5-Fluorouridine is a metabolite of 5-fluorouracil with anticancer activity[1][2][3][4]. 5-fluorouridine inhibits rRNA synthesis of human colon carcinoma cells[3]. 5-Fluorouridine exhibits cytotoxic effect on growth of L1210 cells with an IC50 of 2 nM[4].

Name	5-fluorouridine
Synonyms	L-5-Fluorouridine FURD 5-fluoro-uridine FUR 5-FLUOROIDINE 5-fur 5-Fluor-uridin EINECS 206-260-3 MFCD00036832 5-Fluorouridine 5-FUrd 5-fluoro-uridin 1-(β-D-Ribofuranosyl)-5-fluorouracil Uridine, 5-fluoro- FLUOROURIDINE 5-FU

Description	5-Fluorouridine is a metabolite of 5-fluorouracil with anticancer activity[1][2][3][4]. 5-fluorouridine inhibits rRNA synthesis of human colon carcinoma cells[3]. 5-Fluorouridine exhibits cytotoxic effect on growth of L1210 cells with an IC50 of 2 nM[4].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Wu FL , et al. Gelatinases-stimuli nanoparticles encapsulating 5-fluorouridine and 5-aza-2'-deoxycytidine enhance the sensitivity of gastric cancer cells to chemical therapeutics. Cancer Lett. 2015 Jul 10;363(1):7-16. [2]. Hu N, et al. Strengthening Gastric Cancer Therapy by Trastuzumab-Conjugated Nanoparticles with Simultaneous Encapsulation of Anti-MiR-21 and 5-Fluorouridine. Cell Physiol Biochem. 2017;44(6):2158-2173. [3]. Glazer RI, et al. Association of cell lethality with incorporation of 5-fluorouracil and 5-fluorouridine into nuclear RNA in human colon carcinoma cells in culture. Mol Pharmacol. 1982 Mar;21(2):468-73. [4]. Kanzawa F, et al. Differences between 5-fluoro-2'-deoxyuridine and 5-fluorouridine in their cytotoxic effect on growth of murine lymphoma L5178Y cells in in vivo and in vitro systems. Eur J Cancer. 1980 Aug;16(8):1087-92.

Density	1.8±0.1 g/cm3
Melting Point	182-184 °C
Molecular Formula	C₉H₁₁FN₂O₆
Molecular Weight	262.192
Exact Mass	262.060120
PSA	124.78000
LogP	-1.34
Index of Refraction	1.641
Water Solubility	soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YU8050000

CHEMICAL NAME :: Uridine, 5-fluoro-

CAS REGISTRY NUMBER :: 316-46-1

BEILSTEIN REFERENCE NO. :: 0033662

LAST UPDATED :: 199612

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C9-H11-F-N2-O6

MOLECULAR WEIGHT :: 262.22

WISWESSER LINE NOTATION :: T6NVMVJ EF A- ET5OTJ B1Q CQ DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 384 mg/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: DNA inhibition

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 900 nmol/L

REFERENCE :: CCCCAK Collection of Czechoslovak Chemical Communications. (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1929- Volume(issue)/page/year: 49,2551,1984 *** REVIEWS *** TOXICOLOGY REVIEW 32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York, Springer, 1975 Volume(issue)/page/year: -,49,1975

Personal Protective Equipment	Eyeshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R40
Safety Phrases	S22-S26-S36/37
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	YU8050000
HS Code	2942000000

Precursor 8
55474-11-8 58-96-8 65-46-3 51-21-8
1463-10-1 2560-60-3 119003-30-4 13035-61-5
DownStream 9
51-21-8 32445-75-3 18646-11-2 2341-22-2
62-49-7 739344-73-1 174638-15-4 2797-17-3
116696-69-6

HS Code	2942000000

316-46-1	77180-80-4
18814-21-6	77210-26-5
179383-02-9	69260-71-5
18829-83-9	38817-29-7
50-91-9	50600-39-0
1249521-06-9	1158522-08-7
1249959-17-8	940364-43-2
1192718-36-7	134104-43-1
1368457-75-3	131615-57-1
671215-51-3	1488973-74-5