CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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DA6640000
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CHEMICAL NAME :
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Benzene, pentachloro-
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CAS REGISTRY NUMBER :
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608-93-5
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BEILSTEIN REFERENCE NO. :
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1911550
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LAST UPDATED :
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199806
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DATA ITEMS CITED :
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18
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MOLECULAR FORMULA :
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C6-H-Cl5
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MOLECULAR WEIGHT :
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250.32
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WISWESSER LINE NOTATION :
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GR BG CG DG EG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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1080 mg/kg
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TOXIC EFFECTS :
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Behavioral - general anesthetic Behavioral - tremor
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REFERENCE :
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JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 4(5-6),183,1980
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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>2500 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 4(5-6),183,1980
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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1175 mg/kg
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TOXIC EFFECTS :
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Behavioral - general anesthetic Behavioral - tremor
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REFERENCE :
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JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 4(5-6),183,1980 ** OTHER MULTIPLE DOSE TOXICITY DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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1662 mg/kg/28D-C
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TOXIC EFFECTS :
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Liver - changes in liver weight
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REFERENCE :
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JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 11,663,1983
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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248 mg/kg/15D-C
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TOXIC EFFECTS :
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Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight
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REFERENCE :
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NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-91-3125
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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9 gm/kg/26W-C
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TOXIC EFFECTS :
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Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in leukocyte (WBC) count
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REFERENCE :
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JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 4(5-6),183,1980
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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1738 mg/kg/13W-C
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TOXIC EFFECTS :
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Kidney, Ureter, Bladder - other changes in urine composition Endocrine - adrenal cortex hyperplasia Blood - other changes
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REFERENCE :
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TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 119,181,1993
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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5940 mg/kg/15D-C
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TOXIC EFFECTS :
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Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - tremor Related to Chronic Data - death
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REFERENCE :
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NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-91-3125
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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10909 mg/kg/13W-C
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TOXIC EFFECTS :
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Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases
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REFERENCE :
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NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-91-3125 ** REPRODUCTIVE DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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2 gm/kg
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SEX/DURATION :
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female 6-15 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Specific Developmental Abnormalities - musculoskeletal system
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REFERENCE :
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TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 5,117,1975
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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1802 mg/kg
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SEX/DURATION :
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male 13 week(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
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REFERENCE :
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NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB91-185983
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