100648-13-3

100648-13-3 structure

Name: Triclabendazole sulfoxide
Chemical Name: 6-chloro-5-(2,3-dichlorophenoxy)-2-methylsulfinyl-1H-benzimidazole
CAS Number: 100648-13-3
Molecular Formula: C₁₄H₉Cl₃N₂O₂S
Molecular Weight: 375.65700
Catalog: Chemical reagent Organic reagent Sulfone, sulfoxide compound
Create Date: 2018-03-11 08:00:00
Modify Date: 2024-01-04 12:22:10
Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole, and exhibits anti-parasite effects. Triclabendazole sulfoxide can inhibit membrane transporter ABCG2/BCRP[1][2].

Name	6-chloro-5-(2,3-dichlorophenoxy)-2-methylsulfinyl-1H-benzimidazole
Synonyms	Tcbz-SX Triclabendazole sulfoxide 1H-Benzimidazole,6-chloro-5-(2,3-dichlorophenoxy)-2-(methylsulfinyl) 5-chloro-6-(2,3-dichlorophenoxy)-2-methylsulfinyl-1H-benzimidazole triclabendazole sulphoxide

Description	Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole, and exhibits anti-parasite effects. Triclabendazole sulfoxide can inhibit membrane transporter ABCG2/BCRP[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Membrane Transporter/Ion Channel >> BCRP
References	[1]. Barrera B, et, al. The anthelmintic triclabendazole and its metabolites inhibit the membrane transporter ABCG2/BCRP. Antimicrob Agents Chemother. 2012 Jul;56(7):3535-43. [2]. Robinson MW, et, al. The comparative metabolism of triclabendazole sulphoxide by triclabendazole-susceptible and triclabendazole-resistant Fasciola hepatica. Parasitol Res. 2004 Feb;92(3):205-10.

Hazard Statements	H413
Hazard Codes	Xi
RIDADR	NONH for all modes of transport

68786-66-3

~93%

100648-13-3

Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 22 p. 3129 - 3134

Precursor 1
68786-66-3
DownStream 0