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19685-09-7

19685-09-7 structure
19685-09-7 structure
  • Name: (S)-10-Hydroxycamptothecin
  • Chemical Name: 10-Hydroxycamptothecin
  • CAS Number: 19685-09-7
  • Molecular Formula: C20H16N2O5
  • Molecular Weight: 364.351
  • Catalog: API Antineoplastic agents Natural source antineoplastic agents
  • Create Date: 2018-02-04 08:00:00
  • Modify Date: 2024-01-02 15:36:32
  • (S)-10-Hydroxycamptothecin is a clinical therapy agent against hepatoma.IC50 value:Target:In vitro: In vitro, the 10-hydroxycamptothecin nanosuspensions released the encapsulated drug with nearly zero-order kinetics, and the accumulative release reached 90% within 72 hours. In vitro cytotoxicity assay showed that the 10-hydroxycamptothecin nanosuspensions had significantly enhanced cytotoxicity against HepG2 cells compared to the commercially available 10-hydroxycamptothecin injections [1].In vivo: The in vivo study with H22 tumor-bearing mice and intravenous injection of the drug showed that in contrast to the 10-hydroxycamptothecin injections, the 10-hydroxycamptothecin nanosuspensions exhibited significantly enhanced biodistribution, particularly in the lung (393.40-fold AUC0–24 h, liver (192.35-fold AUC0–24 h, spleen (141.67-fold AUC0–24 h and tumor (64.21-fold AUC0–24 h. The 10-hydroxycamptothecin nanosuspensions also showed improved antitumor therapeutic efficacy over the injections (89.83% vs. 30.56%) [1].
Name 10-Hydroxycamptothecin
Synonyms 10-Hydroxycamptothecin
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, (4S)-
Hydroxycamptothecine
10-Hydroxy camptothecin
10-OH-camptothecin
10-hydroxy-CPT
Camptothecin,hydroxy
MFCD00189425
10-Hydroxycamptochecin
Camptothecin, 10-hydroxy
10-hydroxy-Camptothecin
(4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Hydroxycamptothecin
10-hydroxycamptothecine
Irinotecan Related Compound A
HCPT
(S)-10-Hydroxycamptothecin
Description (S)-10-Hydroxycamptothecin is a clinical therapy agent against hepatoma.IC50 value:Target:In vitro: In vitro, the 10-hydroxycamptothecin nanosuspensions released the encapsulated drug with nearly zero-order kinetics, and the accumulative release reached 90% within 72 hours. In vitro cytotoxicity assay showed that the 10-hydroxycamptothecin nanosuspensions had significantly enhanced cytotoxicity against HepG2 cells compared to the commercially available 10-hydroxycamptothecin injections [1].In vivo: The in vivo study with H22 tumor-bearing mice and intravenous injection of the drug showed that in contrast to the 10-hydroxycamptothecin injections, the 10-hydroxycamptothecin nanosuspensions exhibited significantly enhanced biodistribution, particularly in the lung (393.40-fold AUC0–24 h, liver (192.35-fold AUC0–24 h, spleen (141.67-fold AUC0–24 h and tumor (64.21-fold AUC0–24 h. The 10-hydroxycamptothecin nanosuspensions also showed improved antitumor therapeutic efficacy over the injections (89.83% vs. 30.56%) [1].
Related Catalog
References

[1]. Min Liu, et al. Intracellular delivery of 10-hydroxycamptothecin with targeted nanostructured lipid carriers against multidrug resistance . Journal of Drug Targeting.

[2]. Min Liu, et al. Intracellular delivery of 10-hydroxycamptothecin with targeted nanostructured lipid carriers against multidrug resistance. J Drug Target, Early Online: 1–8
Density 1.6±0.1 g/cm3
Boiling Point 820.7±65.0 °C at 760 mmHg
Melting Point 265-270°C
Molecular Formula C20H16N2O5
Molecular Weight 364.351
Flash Point 450.1±34.3 °C
Exact Mass 364.105927
PSA 101.65000
LogP 1.32
Vapour Pressure 0.0±3.1 mmHg at 25°C
Index of Refraction 1.777
Storage condition -20°C Freezer

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UQ0491700
CAS REGISTRY NUMBER :
19685-09-7
LAST UPDATED :
198305
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C20-H16-N2-O5.H2-O
MOLECULAR WEIGHT :
382.40

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
104 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Human Cells - not otherwise specified
DOSE/DURATION :
100 ug/L
REFERENCE :
YHHPAL Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1953- Suspended 1966-78. Volume(issue)/page/year: 21,492,1986
RIDADR NONH for all modes of transport
HS Code 2934999090
HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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