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91421-42-0

91421-42-0 structure
91421-42-0 structure
  • Name: rubitecan
  • Chemical Name: 9-Nitrocamptothecin
  • CAS Number: 91421-42-0
  • Molecular Formula: C20H15N3O6
  • Molecular Weight: 393.350
  • Catalog: API Antineoplastic agents Natural source antineoplastic agents
  • Create Date: 2018-06-01 08:00:00
  • Modify Date: 2025-08-25 10:31:46
  • Rubitecan (RFS 2000), a camptothecin derivative, is an orally active topoisomerase I inhibitor with broad antitumor activity, and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells[1][2][3].

Name 9-Nitrocamptothecin
Synonyms rubitecan
MFCD06656294
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-10-nitro-, (4S)-
PYRIDOXINE 3,4-DIPALMITATE
9-nitro-20(s)-camptothecin
1H-PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLINE-3,14(4H,12H)-DIONE,4-ETHYL-4-HYDROXY-10-NITRO-, (4S)-
(4S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Orathecin
Description Rubitecan (RFS 2000), a camptothecin derivative, is an orally active topoisomerase I inhibitor with broad antitumor activity, and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells[1][2][3].
Related Catalog
Target

Topoisomerase I[1]

In Vitro Rubitecan (RFS 2000) inhibits U-CH1, U-CH2, and CCL4 cells with IC50s 0.32, 0.83, and 7.7 µM, respectively[4].
References

[1]. Burris HA 3rd, et al. Phase II trial of oral rubitecan in previously treated pancreatic cancer patients. Oncologist. 2005 Mar;10(3):183-90.

[2]. Rubitecan: 9-NC, 9-Nitro-20(S)-camptothecin, 9-nitro-camptothecin, 9-nitrocamptothecin, RFS 2000, RFS2000. Drugs R D. 2004;5(5):305-11.

[3]. Rubitecan

[4]. Xia M, et al. Identification of repurposed small molecule drugs for chordoma therapy. Cancer Biol Ther. 2013 Jul;14(7):638-47.

Density 1.6±0.1 g/cm3
Boiling Point 816.3±65.0 °C at 760 mmHg
Melting Point 182-186ºC
Molecular Formula C20H15N3O6
Molecular Weight 393.350
Flash Point 447.5±34.3 °C
Exact Mass 393.096100
PSA 127.24000
LogP 1.38
Vapour Pressure 0.0±3.1 mmHg at 25°C
Index of Refraction 1.762
Storage condition Room temp
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
RTECS UQ0493300
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