Name | dydrogesterone |
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Synonyms |
Dydrogesterone
D6-Retroprogesterone δ6-Retroprogesterone 9β,10α-Pregna-4,6-diene-3,20-dione (8CI) 9b,10a-Pregna-4,6-diene-3,20-dione (8S,9R,10S,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one (9β,10α)-Pregna-4,6-diene-3,20-dione EINECS 205-806-8 6-Dehydro-9b,10a-progesterone MFCD00867864 10a-Isopregnenone 6-Dehydroretroprogesterone 6-Dehydro-9β,10α-progesterone (9b,10a)-Pregna-4,6-diene-3,20-dione Pregna-4,6-diene-3,20-dione, (9β,10α)- |
Description | Dydrogesterone(Duphaston) is a potent, orally active progestogen indicated in a wide variety of gynaecological conditions related to progesterone deficiency.IC50 value:Target: Progesterone ReceptorDydrogesterone is a potent, orally active progestogen indicated in a wide variety of gynaecological conditions related to progesterone deficiency. Although similar in molecular structure and pharmacological effects to endogenous progesterone. It is orally active at far lower doses. Its freedom from estrogenic, androgenic, anabolic, corticoid and other undesirable hormonal effects gives it additional benefits over most other synthetic progestogens.Dydrogesterone has also been registered as hormone replacement therapy (HRT) to counteract the negative effects of unopposed estrogen on the endometrium in women with an intact uterus. Dydrogesterone is relatively safe and well tolerated, and does not exhibit the androgenic side effects that are common with some other progestins, like medroxyprogesterone. |
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Related Catalog | |
References |
Density | 1.1±0.1 g/cm3 |
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Boiling Point | 462.8±45.0 °C at 760 mmHg |
Melting Point | 168-173°C |
Molecular Formula | C21H28O2 |
Molecular Weight | 312.446 |
Flash Point | 172.2±25.7 °C |
Exact Mass | 312.208923 |
PSA | 34.14000 |
LogP | 3.58 |
Vapour Pressure | 0.0±1.1 mmHg at 25°C |
Index of Refraction | 1.557 |
Storage condition | Refrigerator |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Safety Phrases | S26-S37/39 |
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RIDADR | 3276 |
WGK Germany | 3 |
Packaging Group | III |
Hazard Class | 6.1 |
~% 152-62-5 |
Literature: Recueil des Travaux Chimiques des Pays-Bas, , vol. 80, p. 43 - 46 |
Precursor 1 | |
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DownStream 0 |