Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Fmoc-L-His(Trt)-OH
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
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109425-51-6

109425-51-6 structure

Name: Fmoc-His(Trt)-OH
Chemical Name: N-Fmoc-N'-trityl-L-histidine
CAS Number: 109425-51-6
Molecular Formula: C₄₀H₃₃N₃O₄
Molecular Weight: 619.708
Catalog: Biochemical Amino acids and their derivatives Histidine derivative
Create Date: 2018-12-07 11:41:55
Modify Date: 2026-07-19 18:48:47
Fmoc-His(Trt)-OH has trityl (Trt) group to protect the side-chain of His. Fmoc-His(Trt)-OH has Fmoc group to protect -αNH2. Fmoc-His(Trt)-OH can be used for solid phase synthesis of peptides, providing protection against racemization and by-product formation[1].

Name	N-Fmoc-N'-trityl-L-histidine
Synonyms	N-[(9H-FLUOREN-9-YLMETHOXY)carbonyl]-1-(TRIPHENYLMETHYL)-L-HISTIDINE NA-FMOC-NIM-TRITYL-L-HISTIDINE Fmoc-Histidine-(trt)-OH FMoc-His(Trt)-OH N-α-FMoc-N-iM-trityl-L-histidine Fomc-His(Trt)-OH Nalpha-FMOC-N-trityl-L-histidine NALPHA-9-Fluorenylmethoxycbonyl-N-imidazole-(trityl)-L-histidine Nα-Fmoc-τ-trityl-L-histidine L-HISTIDINE-N-FMOC, N-IM-TRITYL N-ALPHA-9-FLUORENYLMETHOXYCBONYL-NIM-TRITYL-L-HISTIDINE N-FMOC-N-TRITYL-L-HISTIDINE N-Fmoc-N'-trityl-L-h L-Histidine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-1-(triphenylmethyl) Nα-Fmoc-N(im)-trityl-L-histidine N-ALPHA-(9-FLUORENYLMETHOXYCBONYL)-N-TAU-TRITYL-L-HISTIDINE N-ALPHA-(9-FLUORENYLMETHYLOXYCBONYL)-N-IM-TRITYL-L-HISTIDINE FMOC-HIS(1-TRT)-OH Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-tele-(triphenylmethyl)-L-histidine> FMOC-N-IM-TRITYL-L-HISTIDINE (FMOC-L-HIS(TRT)-OH) Nα-[(9H-Fluoren-9-ylMethoxy)carbonyl]-tele-(triphenylMethyl)-L-histidine Fmoc-His(Trt)-OH >= (sum of enantiomers, HPLC) (S)-2-((((9H-fluoren-9-yl)Methoxy)carbonyl)amino)-3-(1-trityl-1H-iMidazol-4-yl)propanoic acid FMOC-N-IM-TRITYL-L-HISTIDINE FMOC-L-HISTIDINE(TRITYL) Fmoc-L-histidine(2-chlorotrityl resin)amide Nalpha-Fmoc-tele-trityl-L-histidine N-9-Fluorenylmethoxycbonyl-N'-trityl-L-histidine FMOC-HIS(TRITYL)-OH N-FMOC-HIS(TRITYL RESIN)-NH2 N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-(triphenylmethyl)-L-histidine, FMOC-L-HIS(TRT)-OH N-FMoc-1-trityl-L-histidine (9H-Fluoren-9-yl)MethOxy]carbonyl His(Trt)-OH N-ALPHA-FMOC-N-IM-TRITYL-L-HISTIDINE 2-[[4b,8a,9,9a-tetrahydro-4aH-fluoren-9-ylmethoxy(oxo)methyl]amino]-3-[1-(triphenylmethyl)-4-imidazolyl]propanoic acid N-Fmoc-N'-trityL Fmoc-L-His(trityl resin)-NH2 Fmoc-His(trityl resin)-NH2 Na-Fmoc-Nim-trityl-L-histidine FMOC-L-HIS(TRITYL) Nalpha-[(9H-Fluoren-9-ylmethoxy)carbonyl]-tele-(triphenylmethyl)-L-histidine FMOC-HIS(TRT)-OH FMOC-HIS(T-TRT)-OH Fmoc-his(trityl)-OH, Fmoc-His(Trt)-OH, Nα-Fmoc-N(im)-trityl-L-histidine trityl-L-histidine N^a-FMoc-1-trityl-L-histidine Fmoc-His(tau-Trt)-OH Nalpha-(9-fluorenylmethoxycbonyl)-N-trityl-L-histidine FMOC-L-HISTIDINE (TRT) MFCD00043332 N-Fmoc-N'-Trityl-L-Histidine N-α-Fmoc-N-im-trityl-L-histidine N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-trityl-L-histidine N-alpha-FMOC-N-Trityl-L-histidine EINECS 439-640-4 FMOC-HIS(TRT)-OH G (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-[1-(triphenylmethyl)-1H-imidazol-4-yl]propanoic acid (2S)-2-(9H-Fluoren-9-ylmethoxycbonylamino)-3-(1-tritylimidazol-4-yl)propanoic acid FMOC-HIS(TRT) Nalpha-Fmoc-tele-trityl-L-histidine Fmoc-His(Trt)-OH (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(1-tritylimidazol-4-yl)propanoic acid FMOC-HISTIDINE(1-TRT)-OH Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-τ-(triphenylmethyl)-L-histidine Nα-Fmoc-Nim-trityl-L-histidine (HPLC, Chiral purity) N-(ALPHA)-FMOC-N-(TRITYL)-L-HISTIDINE

Description	Fmoc-His(Trt)-OH has trityl (Trt) group to protect the side-chain of His. Fmoc-His(Trt)-OH has Fmoc group to protect -αNH2. Fmoc-His(Trt)-OH can be used for solid phase synthesis of peptides, providing protection against racemization and by-product formation[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Yi Y, et, al. Suppression of Simultaneous Fmoc-His(Trt)-OH Racemization and Nα-DIC-Endcapping in Solid-Phase Peptide Synthesis through Design of Experiments and Its Implication for an Amino Acid Activation Strategy in Peptide Synthesis. Org. Process Res. Dev. 2022 Jun 27.

Density	1.2±0.1 g/cm3
Boiling Point	811.7±65.0 °C at 760 mmHg
Melting Point	150-155 °C(lit.)
Molecular Formula	C₄₀H₃₃N₃O₄
Molecular Weight	619.708
Flash Point	444.7±34.3 °C
Exact Mass	619.247131
PSA	93.45000
LogP	8.03
Vapour Pressure	0.0±3.1 mmHg at 25°C
Index of Refraction	1.657
Storage condition	2-8°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	26
RIDADR	NONH for all modes of transport
WGK Germany	3

82911-69-1

35146-32-8

~56%

109425-51-6

Literature: Nowshuddin, Shaik; Rao; Reddy, A. Ram Synthetic Communications, 2009 , vol. 39, # 11 p. 2022 - 2031

28920-43-6

35146-32-8

~73%

109425-51-6

Literature: Barlos, Kleomenis; Mamos, Petros; Papaioannou, Dionysios; Patrianakou, Stella; Sanida, Chariklia; Schaefer, Wolfram Liebigs Annalen der Chemie, 1987 , p. 1025 - 1030

Precursor 3
82911-69-1 35146-32-8 28920-43-6
DownStream 4
35146-32-8 49557-75-7 52530-60-6 121377-67-1

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