15687-37-3
15687-37-3 structure
- Name: naftazone
- Chemical Name: [(E)-(1-oxonaphthalen-2-ylidene)amino]urea
- CAS Number: 15687-37-3
- Molecular Formula: C11H9N3O2
- Molecular Weight: 215.20800
- Catalog: API Blood system medication Anticoagulant and antiplatelet drugs
- Create Date: 2018-02-25 08:00:00
- Modify Date: 2024-01-04 18:45:05
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Naftazone is a naphthoquinone derivative, it can be used for the research of venous insufciency. Naftazone protects blood vessels, increases venous tonicity and capillary resistance, and improves lymphatic and venous circulation[1][2].
| Name | [(E)-(1-oxonaphthalen-2-ylidene)amino]urea |
|---|---|
| Synonyms |
Mediaven
Naftazone (INN) Naftazona Naftazonum Naftazone 1,2-Naphthochinon-2-semicarbazon [1,2]naphthoquinone-2-semicarbazone Mediavene 1,2-naphthoquinone semicarbazone Karbinone Mediaven (TN) |
| Description | Naftazone is a naphthoquinone derivative, it can be used for the research of venous insufciency. Naftazone protects blood vessels, increases venous tonicity and capillary resistance, and improves lymphatic and venous circulation[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Naftazone (0.5-50 μM; 1 h) reduces glutamate release from mouse cerebellum synaptosomes[1]. |
| In Vivo | Naftazone (10 and 100 mg/kg; p.o. once per day for 15 days) affects glutamate content in cerebro spinal fluid[1]. Naftazone (50 mg/kg; i.p. once per day for 5 days) affects platelet function in rats[2]. Animal Model: Male rats[1] Dosage: 10 and 100 mg/kg Administration: Oral gavage; 10 and 100 mg/kg once per day; for 15 days Result: Significantly reduced glutamate content in cerebro spinal fluid of rats. Animal Model: Wistar rats[2] Dosage: 50 mg/kg Administration: Intraperitoneal injection ; 50 mg/kg once daily for 5 days Result: Reduced the height of platelet aggregation induced by ADP, significantly increased the platelet disaggregation induced by collagen and reduced fibrinogen binding to 2.5 or 5 μM ADP-stimulated platelet. |
| Density | 1.4g/cm3 |
|---|---|
| Molecular Formula | C11H9N3O2 |
| Molecular Weight | 215.20800 |
| Exact Mass | 215.06900 |
| PSA | 84.55000 |
| LogP | 2.01160 |
| Index of Refraction | 1.678 |
| HS Code | 2928000090 |
|---|
|
~78%
15687-37-3 |
| Literature: Anitha, Panneerselvam; Viswanathamurthi, Periasamy; Misini, Bashkim; Linert, Wolfgang Monatshefte fur Chemie, 2013 , vol. 144, # 12 p. 1787 - 1795 |
|
~%
15687-37-3 |
| Literature: Thiele; Barlow Justus Liebigs Annalen der Chemie, 1898 , vol. 302, p. 329 |
| HS Code | 2928000090 |
|---|---|
| Summary | 2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |