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55985-32-5

55985-32-5 structure

Name: Nicardipine
Chemical Name: 5-O-[2-[benzyl(methyl)amino]ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS Number: 55985-32-5
Molecular Formula: C₂₆H₂₉N₃O₆
Molecular Weight: 479.52500
Catalog: API Circulatory system medication Prevention and treatment of angina pectoris
Create Date: 2018-06-13 11:43:17
Modify Date: 2024-01-02 20:10:18
Nicardipine(YC-93) is a calcium channel blocker that has been widely used to control blood pressure in severe hypertension following events such as ischemic stroke, traumatic brain injury, and intracerebral hemorrhage.

Name	5-O-[2-[benzyl(methyl)amino]ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Synonyms	Cardene IV Cardene SR Nicardipino MFCD00216027 nicardipine Nicardipine LA Nicardipinum EINECS 259-932-3

Description	Nicardipine(YC-93) is a calcium channel blocker that has been widely used to control blood pressure in severe hypertension following events such as ischemic stroke, traumatic brain injury, and intracerebral hemorrhage.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Neurological Disease
References	[1]. Huang BR, et al. Anti-neuroinflammatory effects of the calcium channel blocker nicardipine on microglial cells: implications for neuroprotection. PLoS One. 2014 Mar 12;9(3):e91167. [2]. Amenta F, et al. Vascular and neuronal hypertensive brain damage: protective effect of treatment with nicardipine. J Hypertens Suppl. 1996 Oct;14(3):S29-35. [3]. Gasior M, et al. Influence of nicardipine, nimodipine and flunarizine on the anticonvulsant efficacy of antiepileptics against pentylenetetrazol in mice. J Neural Transm. 1996;103(7):819-31.

Density	1.23 g/cm3
Boiling Point	603.4ºC at 760 mmHg
Melting Point	136-138ºC
Molecular Formula	C₂₆H₂₉N₃O₆
Molecular Weight	479.52500
Flash Point	318.7ºC
Exact Mass	479.20600
PSA	113.69000
LogP	4.52980
Storage condition	-20℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US7972050

CHEMICAL NAME :: 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-(benzylmethylamino)ethyl methyl ester

CAS REGISTRY NUMBER :: 55985-32-5

LAST UPDATED :: 199712

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C26-H29-N3-O6

MOLECULAR WEIGHT :: 479.58

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 35,915,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 11800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4710505

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 305 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4824855

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9700 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4672068

88488-49-7

55985-32-5

Literature: Chemical and Pharmaceutical Bulletin, , vol. 43, # 5 p. 788 - 796

170748-98-8

55985-32-5

Literature: Chemical and Pharmaceutical Bulletin, , vol. 43, # 5 p. 788 - 796

85677-95-8

55985-32-5

Literature: Chemical and Pharmaceutical Bulletin, , vol. 34, # 4 p. 1589 - 1606

103785-48-4

103-67-3

~78%

55985-32-5

Literature: Ohno; Komatsu; Mizukoshi; Ichihara; Nakamura; Morishima; Sumita Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 4 p. 1589 - 1606

Precursor 4
88488-49-7 170748-98-8 85677-95-8 103-67-3
DownStream 4
39562-70-4 59875-58-0 63675-72-9 74936-72-4

55985-32-5	1743-60-8
106664-28-2	54527-84-3
69441-18-5	76093-35-1
76093-36-2	156880-36-3
54527-65-0	54527-73-0
1705834-96-3	2034303-99-4
1158522-08-7	2034470-45-4
1823867-32-8	940364-43-2
134104-43-1	131615-57-1
6906-52-1	930439-75-1