63675-72-9
63675-72-9 structure
- Name: Nisoldipine
- Chemical Name: methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- CAS Number: 63675-72-9
- Molecular Formula: C20H24N2O6
- Molecular Weight: 388.414
- Catalog: API Circulatory system medication Prevention and treatment of angina pectoris
- Create Date: 2018-04-04 08:00:00
- Modify Date: 2026-06-30 17:50:39
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Nisoldipine(BAY-k 5552; Sular) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM. IC50 value: 10 nMTarget: L-type Cav1.2Nisoldipine is a potent blocker of L-type calcium channels. Nisoldipine binds directly to inactive calcium channels stabilizing their inactive conformation Similar to other DHP CCBs. Nisoldipine displays selectivity for arterial smooth muscle cells due to great number of inactive channels and the α1 subunit of the channel. Nisoldipine is about 30 times less selective for delayed-rectifier K+ channels than for L-type Ca2+ channels, which inhibits IKr (rapidly activating delayed-rectifier K+ current) with IC50 of 23 μM, and IKs (slowly activating delayed-rectifier K+ current)with IC50 of 40 μM in guinea-pig ventricular myocytes. Nisoldipine also displays antioxidant potency with IC50 of 28.2 μM both before and after the addition of active oxygen.
| Name | methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
|---|---|
| Synonyms |
Nisoldipine, >=
2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicboxylic acid O3-methyl ester O5-(2-methylpropyl) ester (±)-Isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicboxylate Nisoldipine-d6 ZADIPINA Isobutyl Methyl 1,4-Dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylate Nisoldipine-d4 Ninobucin 5-pyridinedicboxylicacid,1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-met Baymycard UNII:4I8HAB65SZ 2，6-Dimethyl-4-(2-nitmphenyl)-1，4-dihydro-3，5-pyridinedicboxylic acid methyl 2-methylpropyl ester 3,5-Pyridinedicboxylicacid, 1,4-dihydro-2,6-diMethyl-4-(2-nitrophenyl)-, 3-Methyl 5-(2-Methylpropyl)ester 3-Isobutyl 5-Methyl 2,6-diMethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicboxylate 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicboxylic Acid Isobutyl Methyl Ester Nikameal 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicboxylic acid 3-methyl 5-isobutyl ester Nisoldipine Nisoldipine 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, methyl 2-methylpropyl ester Nisoldipine 100 μg/mL in Methanol Sul hexakis(dihydrogen phosphate) Nisoldipinem Nisoldipine(BAY-k Nisoldipine //BP Isobutyl methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Baymycd, Norvasc, Syscor, Zadipina, 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicboxylic Acid Methyl 2-methylpropyl Ester SYSCOR 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicboxylic acid-3-methyl 5-(2-methylpropyl) ester Syscor Syseor 3,5-Pyridinedicboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, methyl 2-methylpropyl ester (9CI) EINECS 264-407-7 NISOLDIPINE NON STERILE BULK DRUG SUBSTANCE 3-Methyl 5-(2-Methylpropyl) (4R)-2,6-diMethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicboxylate NisoldipineQ: What is Nisoldipine Q: What is the CAS Number of Nisoldipine Q: What is the storage condition of Nisoldipine Q: What e the applications of Nisoldipine NisoL ISOBUTYL METHYL (- 1,4-DIHYDRO-2,6-DIMETHYL-4-(2-NITROPHENYL)-3,5-PYRIDINEDICBOXYLATE MFCD00478055 NORVASC Nisomynd 3-O-methyl 5-O-(2-methylpropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Nisoldipin NISOLDIPINE BAYMYCD Isobutyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate Nisoldipine - Bio-X Isobutyl methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate hyl2-methylpropylester BAY K Isobutyl 1,4-Dihydro-5-methoxycarbonyl-2,6-dimethyl-4-(2-nitrophenyl)-3-pyridinecarboxylate Nisoldipine (Sul 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 2-methylpropyl ester NISOLIDIPINE methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicboxylate Nisocor 2,6-Dimethyl-3-carbomethoxy-4-(2-nitrophenyl)-5-carbisobutoxy-1,4-dihydropyridine 1,4-DIHYDRO-2,6-DIMETHYL-4-(2-NITROPHENYL)-3,5-PYRIDINEDICBOXYLIC ACID METHYL 2-METHYLPROPYL ESTER Nisoldipine> 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid Methyl 2-Methylpropyl Ester Zadipina |
| Description | Nisoldipine(BAY-k 5552; Sular) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM. IC50 value: 10 nMTarget: L-type Cav1.2Nisoldipine is a potent blocker of L-type calcium channels. Nisoldipine binds directly to inactive calcium channels stabilizing their inactive conformation Similar to other DHP CCBs. Nisoldipine displays selectivity for arterial smooth muscle cells due to great number of inactive channels and the α1 subunit of the channel. Nisoldipine is about 30 times less selective for delayed-rectifier K+ channels than for L-type Ca2+ channels, which inhibits IKr (rapidly activating delayed-rectifier K+ current) with IC50 of 23 μM, and IKs (slowly activating delayed-rectifier K+ current)with IC50 of 40 μM in guinea-pig ventricular myocytes. Nisoldipine also displays antioxidant potency with IC50 of 28.2 μM both before and after the addition of active oxygen. |
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| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 505.8±50.0 °C at 760 mmHg |
| Melting Point | 147-148°C |
| Molecular Formula | C20H24N2O6 |
| Molecular Weight | 388.414 |
| Flash Point | 259.7±30.1 °C |
| Exact Mass | 388.163422 |
| PSA | 110.45000 |
| LogP | 4.38 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.544 |
| Storage condition | -20°C Freezer |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H312 |
| Precautionary Statements | P280 |
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38:Irritating to eyes, respiratory system and skin . |
| Safety Phrases | S26-S36 |
| RIDADR | 3077 |
| WGK Germany | 2 |
| RTECS | 3425000 |
| HS Code | 2942000000 |
|
~52%
63675-72-9 |
| Literature: ERREGIERRE, S.P.A. Patent: WO2004/2958 A1, 2004 ; Location in patent: Page 4-5 ; |
|
~%
63675-72-9 |
| Literature: US5786344 A1, ; |
| Precursor 4 | |
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| DownStream 1 | |
| HS Code | 2942000000 |
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