Henan Tianfu Chemical Co., Ltd.
China
Product Name: Naloxone API
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson
Email: info@tianfuchem.com

465-65-6

465-65-6 structure

Name: Naloxone
Chemical Name: naloxone
CAS Number: 465-65-6
Molecular Formula: C₁₉H₂₁NO₄
Molecular Weight: 327.37
Catalog: API Special medicine Antidote
Create Date: 2018-08-06 19:54:23
Modify Date: 2026-07-01 14:15:06
Naloxone is an antagonist of Opioid receptor. Naloxone alleviates opioid-overdose-induced respiratory depression. Naloxone may cause pulmonary edema and cardiac arrhythmias[1].

Name	naloxone
Synonyms	l-naloxone Narcon 1-n-allyl-14-hydroxynordihydromorphinone 12-allyl-7,7a,8,9-tetrahydro-3,7a-dihydroxy-4ah-8,9c-iminoethanophenanthro(4,5 bcd]furan-5(6h)-one (4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one C07252 1-n-allyl-7,8-dihydro-14-hydroxynormorphinone l-n-allyl-7,8-dihydro-14-hydroxynormorphinone Naloxone, (controlled) 17-allyl-4,5alpha-oxy-3,14-dihydroxymorphinan-6-one l-n-allyl-14-hydroxynordihydromorphinone 12-allyl-7,7a,8,9-tetrahydro-3,7a-dihydroxy-4ah-8,9c-iminoethanophenanthro(4 bcd)furanone NALOXONE Narcanti 17-allyl-4,5alpha-oxy-3,14-dihydroxy-morphinan-6-on n-allyl-noroxymorphone Naloxone //BP (4R)-6,10aβ-Dihydroxy-11-allyl-4α,5-oxy-10β,4aβ-iminoethano)-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-3-one 17-allyl-4,5-alpha-oxy-3,14-dihydroxymorphinan-6-one Methanol (test Naloxone, 1.0 mg/mL） l-Naloxone (5alpha)-3,14-Dihydroxy-17-prop-2-en-1-yl-4,5-oxymorphinan-6-one Morphinan-6-one,4,5-oxy-3,14-dihydroxy-17-(2-propen-1-yl)-, (5a) 12-allyl-7,7a,8,9-tetrahydro-3,7a-dihydroxy-4ah-8,9c-iminoethanophenanthro[4,5 Naloxone (1.0 mg/mL in Methanol) 5-oxy-3,14-dihydroxy-17-(2-propenyl)-(5alpha)-morphinan-6-on Nafoxone Hydrochloride 17-Allyl-4,5α-oxy-3,14-dihydroxymorphinan-6-one Morphinan-6-one, 4,5-oxy-3,14-dihydroxy-17-(2-propen-1-yl)-, (5α) Narcan Normorphinone, N-allyl-7,8-dihydro-14-hydroxy- (7CI) 5-bcd)furanone 9: PN: WO03037310 FIGURE: 4 claimed sequence Naloxonum Naloxone Base (5α)-4,5-oxy-3,14-dihydroxy-17-(2-propen-1-yl)morphinan-6-one Naloxone impurity 12-Allyl-7,7a,8,9-tetrahydro-3,7a-dihydroxy-4aH-8,9c-iminoethanophenanthro[4,5-bcd]furan-5(6H)-one Nalone [14C]-Naloxone [3H]-Naloxone EN 1530 base 4,5-alpha-oxy-3,14-dihydroxy-17-(2-propenyl)-morphinan-6-on n-Allylnoroxymorphone Naloxona Morphinan-6-one, 4,5-oxy-3,14-dihydroxy-17-(2-propenyl)-, (5a)- (9CI) Morphinan-6-one, 17-allyl-4,5a-oxy-3,14-dihydroxy- (8CI) Naloxone solution Naloxone API

Description	Naloxone is an antagonist of Opioid receptor. Naloxone alleviates opioid-overdose-induced respiratory depression. Naloxone may cause pulmonary edema and cardiac arrhythmias[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
References	[1]. van Dorp E, et al. Naloxone treatment in opioid addiction: the risks and benefits. Expert Opin Drug Saf. 2007 Mar;6(2):125-32.

Density	1.43 g/cm3
Boiling Point	532.8ºC at 760 mmHg
Melting Point	184ºC
Molecular Formula	C₁₉H₂₁NO₄
Molecular Weight	327.37
Flash Point	276.1ºC
Exact Mass	327.14700
PSA	70.00000
LogP	1.23930
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QD2260000

CHEMICAL NAME :: Morphinan-6-one, 4,5-alpha-epoxy-3,14-dihydroxy-17-(2-propenyl)-

CAS REGISTRY NUMBER :: 465-65-6

LAST UPDATED :: 199806

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C19-H21-N-O4

MOLECULAR WEIGHT :: 327.41

WISWESSER LINE NOTATION :: T B6566 B6/CO 4ABBC R BX FV HO PN GHT&&TTJ CQ JQ P2U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 260 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 30 mg/kg

SEX/DURATION :: female 16-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - gastrointestinal system Reproductive - Effects on Newborn - behavioral Reproductive - Effects on Newborn - physical

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

DOSE :: 500 ug/kg

SEX/DURATION :: female 17-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - behavioral

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Human Cells - not otherwise specified

DOSE/DURATION :: 120 umol/L/24H

REFERENCE :: JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985- Volume(issue)/page/year: 78,519,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4324 No. of Facilities: 14 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 306 (estimated) No. of Female Employees: 121 (estimated)

Symbol	GHS02, GHS06, GHS08
Signal Word	Danger
Hazard Statements	H225-H301 + H311 + H331-H370
Precautionary Statements	P210-P260-P280-P301 + P310-P311
Hazard Codes	F,T
Risk Phrases	11-23/24/25-39/23/24/25
Safety Phrases	7-16-36/37-45
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution

Precursor 7
33522-95-1 106-95-6 646032-89-5 1826-67-1
107-05-1 2155-94-4 76-41-5
DownStream 4
20410-95-1 53154-12-4 33522-95-1 50510-01-5

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