148296-46-2

148296-46-2 structure

Name: GDP-α-D-mannose disodium
Chemical Name: disodium,[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] [(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] phosphate
CAS Number: 148296-46-2
Molecular Formula: C₁₆H₂₃N₅Na₂O₁₆P₂
Molecular Weight: 649.30500
Catalog: Research Areas Metabolic Disease
Create Date: 2017-04-06 15:39:31
Modify Date: 2024-01-10 18:47:56
GDP-α-D-mannose disodium is the donor substrate for mannosyltransferases and the precursor of GDP-β-L-fucose. GDP-α-D-mannose disodium gives a competitive inhibition with respect to GTP (Ki 14.7 μM) and an uncompetitive inhibition with respect to mannose-1-P (Ki 115 μM)[1].

Name	disodium,[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] [(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] phosphate
Synonyms	GDP-D-mannose disodium salt Guanosine 5 inverted exclamation marka-diphospho-\|A-D-mannose disodium salt

Description	GDP-α-D-mannose disodium is the donor substrate for mannosyltransferases and the precursor of GDP-β-L-fucose. GDP-α-D-mannose disodium gives a competitive inhibition with respect to GTP (Ki 14.7 μM) and an uncompetitive inhibition with respect to mannose-1-P (Ki 115 μM)[1].
Related Catalog	Research Areas >> Metabolic Disease
In Vitro	GDP-α-D-mannose is the alpha-anomer of GDP-D-mannose.
References	[1]. Elling L, et al. Expression, purification and characterization of recombinant phosphomannomutase and GDP-alpha-D-mannose pyrophosphorylase from Salmonella enterica, group B, for the synthesis of GDP-alpha-D-mannose from D-mannose. Glycobiology. 1996 Sep;6(6):591-7.