GDP-​α-D-​mannose disodium

Modify Date: 2024-01-10 18:47:56

GDP-​α-D-​mannose disodium Structure
GDP-​α-D-​mannose disodium structure
Common Name GDP-​α-D-​mannose disodium
CAS Number 148296-46-2 Molecular Weight 649.30500
Density N/A Boiling Point N/A
Molecular Formula C16H23N5Na2O16P2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of GDP-​α-D-​mannose disodium


GDP-α-D-mannose disodium is the donor substrate for mannosyltransferases and the precursor of GDP-β-L-fucose. GDP-α-D-mannose disodium gives a competitive inhibition with respect to GTP (Ki 14.7 μM) and an uncompetitive inhibition with respect to mannose-1-P (Ki 115 μM)[1].

 Names

Name disodium,[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] [(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] phosphate
Synonym More Synonyms

 GDP-​α-D-​mannose disodium Biological Activity

Description GDP-α-D-mannose disodium is the donor substrate for mannosyltransferases and the precursor of GDP-β-L-fucose. GDP-α-D-mannose disodium gives a competitive inhibition with respect to GTP (Ki 14.7 μM) and an uncompetitive inhibition with respect to mannose-1-P (Ki 115 μM)[1].
Related Catalog
In Vitro GDP-​α-D-​mannose is the alpha-anomer of GDP-D-mannose.
References

[1]. Elling L, et al. Expression, purification and characterization of recombinant phosphomannomutase and GDP-alpha-D-mannose pyrophosphorylase from Salmonella enterica, group B, for the synthesis of GDP-alpha-D-mannose from D-mannose. Glycobiology. 1996 Sep;6(6):591-7.

 Chemical & Physical Properties

Molecular Formula C16H23N5Na2O16P2
Molecular Weight 649.30500
Exact Mass 649.04100
PSA 357.99000
Storage condition -20°C

 Synonyms

GDP-D-mannose disodium salt
Guanosine 5 inverted exclamation marka-diphospho-|A-D-mannose disodium salt